Target
Growth factor receptor-bound protein 2
Ligand
BDBM50139763
Substrate
n/a
Meas. Tech.
ChEMBL_72357 (CHEMBL686444)
IC50
1.4±n/a nM
Citation
 Shi, ZDWei, CQLee, KLiu, HZhang, MAraki, TRoberts, LRWorthy, KMFisher, RJNeel, BGKelley, JAYang, DBurke, TR Macrocyclization in the design of non-phosphorus-containing Grb2 SH2 domain-binding ligands. J Med Chem 47:2166-9 (2004) [PubMed]  Article 
Target
Name:
Growth factor receptor-bound protein 2
Synonyms:
ASH | GRB2 | GRB2 adapter protein | GRB2_HUMAN | Grb2-SH2 | Growth factor receptor-bound protein 2
Type:
Protein
Mol. Mass.:
25205.04
Organism:
Homo sapiens (Human)
Description:
P62993
Residue:
217
Sequence:
MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFLWVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
  
Inhibitor
Name:
BDBM50139763
Synonyms:
CHEMBL306657 | [(E)-(9S,10S,14S,18S)-18-Carbamoylmethyl-14-naphthalen-1-ylmethyl-8,17,20-trioxo-10-(4-phosphonomethyl-phenyl)-7,16,19-triaza-spiro[5.14]icos-11-en-9-yl]-acetic acid | [(E)-(S)-18-Carbamoylmethyl-14-naphthalen-1-ylmethyl-8,20-dioxo-17-(S)-oxo-10-((1S,4S)-4-phosphonomethyl-phenyl)-7,16,19-triaza-spiro[5.14]icos-11-en-9-yl]-acetic acid
Type:
Small organic molecule
Emp. Form.:
C39H47N4O9P
Mol. Mass.:
746.7856
SMILES:
NC(=O)C[C@@H]1NC(=O)C2(CCCCC2)NC(=O)[C@@H](CC(O)=O)[C@H](\C=C\C[C@@H](Cc2cccc3ccccc23)CNC1=O)c1ccc(CP(O)(O)=O)cc1 |t:24|
Structure:
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