Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50144518
Substrate
n/a
Meas. Tech.
ChEBML_201915
Ki
0.090000±n/a nM
Citation
 Glennon, RA; Ismaiel, AM; Ablordeppey, S; El-Ashmawy, M; Fisher, JB Thioxanthene-derived analogs as sigma(1) receptor ligands. Bioorg Med Chem Lett 14:2217-20 (2004) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25124.85
Organism:
Homo sapiens (Human)
Description:
Q99720
Residue:
223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50144518
Synonyms:
1-(5,5-Diphenyl-pentyl)-4-methyl-piperidine | CHEMBL302087
Type:
Small organic molecule
Emp. Form.:
C23H31N
Mol. Mass.:
321.4989
SMILES:
CC1CCN(CCCCC(c2ccccc2)c2ccccc2)CC1
Structure:
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