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Target
5-hydroxytryptamine receptor 2C
Ligand
BDBM50144839
Substrate
n/a
Meas. Tech.
ChEBML_2970
EC50
21±n/a nM
Citation
 Bentley, JM; Adams, DR; Bebbington, D; Benwell, KR; Bickerdike, MJ; Davidson, JE; Dawson, CE; Dourish, CT; Duncton, MA; Gaur, S; George, AR; Giles, PR; Hamlyn, RJ; Kennett, GA; Knight, AR; Malcolm, CS; Mansell, HL; Misra, A; Monck, NJ; Pratt, RM; Quirk, K; Roffey, JR; Vickers, SP; Cliffe, IA Indoline derivatives as 5-HT(2C) receptor agonists. Bioorg Med Chem Lett 14:2367-70 (2004) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 2C
Synonyms:
5-HT-2C | 5-HT2C | 5-HT2C-INI | 5-HT2c VGI | 5-HTR2C | 5-hydroxytryptamine receptor 1C | 5-hydroxytryptamine receptor 2C (5-HT-2C) | 5-hydroxytryptamine receptor 2C (5HT-2C) | 5HT-1C | 5HT2C_HUMAN | HTR1C | HTR2C | Serotonin (5-HT3) receptor | Serotonin 2c (5-HT2c) receptor | Serotonin Receptor 2C
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
51836.79
Organism:
Homo sapiens (Human)
Description:
P28335
Residue:
458
Sequence:
MVNLRNAVHSFLVHLIGLLVWQCDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV
  
Inhibitor
Name:
BDBM50144839
Synonyms:
(S)-2-(6-Ethylsulfanyl-5-fluoro-2,3-dihydro-indol-1-yl)-1-methyl-ethylamine | CHEMBL80731
Type:
Small organic molecule
Emp. Form.:
C13H19FN2S
Mol. Mass.:
254.367
SMILES:
CCSc1cc2N(C[C@H](C)N)CCc2cc1F
Structure:
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