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Target
Peroxisome proliferator-activated receptor gamma
Ligand
BDBM50145720
Substrate
n/a
Meas. Tech.
ChEMBL_153619 (CHEMBL760384)
IC50
2241±n/a nM
Citation
 Xu, Y; Rito, CJ; Etgen, GJ; Ardecky, RJ; Bean, JS; Bensch, WR; Bosley, JR; Broderick, CL; Brooks, DA; Dominianni, SJ; Hahn, PJ; Liu, S; Mais, DE; Montrose-Rafizadeh, C; Ogilvie, KM; Oldham, BA; Peters, M; Rungta, DK; Shuker, AJ; Stephenson, GA; Tripp, AE; Wilson, SB; Winneroski, LL; Zink, R; Kauffman, RF; McCarthy, JR Design and synthesis of alpha-aryloxy-alpha-methylhydrocinnamic acids: a novel class of dual peroxisome proliferator-activated receptor alpha/gamma agonists. J Med Chem 47:2422-5 (2004) [PubMed]  Article 
Target
Name:
Peroxisome proliferator-activated receptor gamma
Synonyms:
NR1C3 | Nuclear receptor subfamily 1 group C member 3 | PPAR-gamma | PPARG | PPARG_HUMAN | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor gamma (PPAR gamma) | Peroxisome proliferator-activated receptor gamma (PPARG) | Peroxisome proliferator-activated receptor gamma (PPARĪ³) | Peroxisome proliferator-activated receptor gamma/Nuclear receptor corepressor 2 | peroxisome proliferator-activated receptor gamma isoform 2
Type:
Nuclear Receptor
Mol. Mass.:
57613.46
Organism:
Homo sapiens (Human)
Description:
P37231
Residue:
505
Sequence:
MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY
  
Inhibitor
Name:
BDBM50145720
Synonyms:
2-{4-[2-(5-Methyl-2-phenyl-oxazol-4-yl)-ethoxy]-benzyl}-2-phenoxy-hexanoic acid | CHEMBL82193
Type:
Small organic molecule
Emp. Form.:
C31H33NO5
Mol. Mass.:
499.5974
SMILES:
CCCCC(Cc1ccc(OCCc2nc(oc2C)-c2ccccc2)cc1)(Oc1ccccc1)C(O)=O
Structure:
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