Target
Retinoic acid receptor RXR-alpha
Ligand
BDBM50146326
Substrate
n/a
Meas. Tech.
ChEBML_196620
EC50
235±n/a nM
Citation
 Gernert, DLNeel, DABoehm, MFLeibowitz, MDMais, DAMichellys, PYRungta, DReifel-Miller, AGrese, TA Design and synthesis of benzofused heterocyclic RXR modulators. Bioorg Med Chem Lett 14:2759-63 (2004) [PubMed]  Article 
Target
Name:
Retinoic acid receptor RXR-alpha
Synonyms:
NR2B1 | Nuclear receptor subfamily 2 group B member 1 | Nuclear receptor subfamily 4 group A member 2 | Nuclear receptor subfamily 4 group A member 2/Retinoic acid receptor RXR-alpha | RXRA | RXRA_HUMAN | Retinoic acid receptor RXR-alpha/gamma | Retinoid X receptor alpha | Retinoid receptor
Type:
PROTEIN
Mol. Mass.:
50820.38
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1456363
Residue:
462
Sequence:
MDTKHFLPLDFSTQVNSSLTSPTGRGSMAAPSLHPSLGPGIGSPGQLHSPISTLSSPINGMGPPFSVISSPMGPHSMSVPTTPTLGFSTGSPQLSSPMNPVSSSEDIKPPLGLNGVLKVPAHPSGNMASFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLIDKRQRNRCQYCRYQKCLAMGMKREAVQEERQRGKDRNENEVESTSSANEDMPVERILEAELAVEPKTETYVEANMGLNPSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQMT
  
Inhibitor
Name:
BDBM50146326
Synonyms:
(E)-3-[3-(2-Ethoxy-3,5-diisopropyl-phenyl)-1H-indazol-5-yl]-but-2-enoic acid | CHEMBL91979
Type:
Small organic molecule
Emp. Form.:
C25H30N2O3
Mol. Mass.:
406.5173
SMILES:
CCOc1c(cc(cc1-c1[nH]nc2ccc(cc12)C(C)=CC(O)=O)C(C)C)C(C)C |w:20.23|
Structure:
Search PDB for entries with ligand similarity: