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Target
Tissue-type plasminogen activator
Ligand
BDBM50148365
Substrate
n/a
Meas. Tech.
ChEMBL_208052 (CHEMBL812494)
IC50
390±n/a nM
Citation
 Gopalsamy, A; Kincaid, SL; Ellingboe, JW; Groeling, TM; Antrilli, TM; Krishnamurthy, G; Aulabaugh, A; Friedrichs, GS; Crandall, DL Design and synthesis of oxadiazolidinediones as inhibitors of plasminogen activator inhibitor-1. Bioorg Med Chem Lett 14:3477-80 (2004) [PubMed]  Article 
Target
Name:
Tissue-type plasminogen activator
Synonyms:
Alteplase | PLAT | Reteplase | TPA_HUMAN | Thrombin receptor protein | Tissue-type plasminogen activator | Tissue-type plasminogen activator (tPA) | Tissue-type plasminogen activator precursor | t-PA | t-Plasminogen Activator (tPA) | t-plasminogen activator
Type:
Enzyme
Mol. Mass.:
62931.08
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
562
Sequence:
MDAMKRGLCCVLLLCGAVFVSPSQEIHARFRRGARSYQVICRDEKTQMIYQQHQSWLRPVLRSNRVEYCWCNSGRAQCHSVPVKSCSEPRCFNGGTCQQALYFSDFVCQCPEGFAGKCCEIDTRATCYEDQGISYRGTWSTAESGAECTNWNSSALAQKPYSGRRPDAIRLGLGNHNYCRNPDRDSKPWCYVFKAGKYSSEFCSTPACSEGNSDCYFGNGSAYRGTHSLTESGASCLPWNSMILIGKVYTAQNPSAQALGLGKHNYCRNPDGDAKPWCHVLKNRRLTWEYCDVPSCSTCGLRQYSQPQFRIKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWILSAAHCFQERFPPHHLTVILGRTYRVVPGEEEQKFEVEKYIVHKEFDDDTYDNDIALLQLKSDSSRCAQESSVVRTVCLPPADLQLPDWTECELSGYGKHEALSPFYSERLKEAHVRLYPSSRCTSQHLLNRTVTDNMLCAGDTRSGGPQANLHDACQGDSGGPLVCLNDGRMTLVGIISWGLGCGQKDVPGVYTKVTNYLDWIRDNMRP
  
Inhibitor
Name:
BDBM50148365
Synonyms:
2-{3-[4-(3,5-Bis-trifluoromethyl-benzyloxy)-phenyl]-1-phenyl-propyl}-[1,2,4]oxadiazolidine-3,5-dione | CHEMBL116137
Type:
Small organic molecule
Emp. Form.:
C26H20F6N2O4
Mol. Mass.:
538.4384
SMILES:
FC(F)(F)c1cc(COc2ccc(CCC(c3ccccc3)n3oc(=O)[nH]c3=O)cc2)cc(c1)C(F)(F)F
Structure:
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