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Target
Mitogen-activated protein kinase 14
Ligand
BDBM50148665
Substrate
n/a
Meas. Tech.
ChEBML_124477
IC50
15000±n/a nM
Citation
 Li, HY; Wang, Y; Yan, L; Campbell, RM; Anderson, BD; Wagner, JR; Yingling, JM Novel and potent transforming growth factor beta type I receptor kinase domain inhibitor: 7-amino 4-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)-quinolines. Bioorg Med Chem Lett 14:3585-8 (2004) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM50148665
Synonyms:
4-(2-(6-isopropylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline | 4-[2-(6-Isopropyl-pyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl]-quinoline | CHEMBL120245
Type:
Small organic molecule
Emp. Form.:
C23H22N4
Mol. Mass.:
354.4476
SMILES:
CC(C)c1cccc(n1)-c1nn2CCCc2c1-c1ccnc2ccccc12 |(11.23,-4.96,;10.3,-3.73,;10.9,-2.31,;8.78,-3.92,;8.18,-5.36,;6.64,-5.57,;5.71,-4.32,;6.32,-2.91,;7.85,-2.71,;5.38,-1.68,;5.83,-.21,;4.55,.67,;4.06,2.11,;2.54,2.09,;2.08,.62,;3.34,-.26,;3.84,-1.71,;2.9,-2.93,;3.49,-4.36,;2.55,-5.57,;1.03,-5.38,;.44,-3.94,;-1.09,-3.76,;-1.68,-2.33,;-.74,-1.1,;.78,-1.3,;1.37,-2.73,)|
Structure:
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