Target
Corticotropin-releasing factor receptor 1
Ligand
BDBM50148883
Substrate
n/a
Meas. Tech.
ChEBML_51104
Ki
3.9±n/a nM
Citation
 Chen, CWilcoxen, KMHuang, CQMcCarthy, JRChen, TGrigoriadis, DE Optimization of 3-phenylpyrazolo[1,5-a]pyrimidines as potent corticotropin-releasing factor-1 antagonists with adequate lipophilicity and water solubility. Bioorg Med Chem Lett 14:3669-73 (2004) [PubMed]  Article
Target
Name:
Corticotropin-releasing factor receptor 1
Synonyms:
CRF-R | CRF-R2 Alpha | CRF1 | CRH-R 1 | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1
Type:
Enzyme
Mol. Mass.:
50744.31
Organism:
Homo sapiens (Human)
Description:
P34998
Residue:
444
Sequence:
MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
  
Inhibitor
Name:
BDBM50148883
Synonyms:
CHEMBL334237 | [3-(2,4-Dimethoxy-phenyl)-2,5-dimethyl-3H-pyrazolo[1,5-a]pyrimidin-7-yl]-(1-ethyl-propyl)-amine
Type:
Small organic molecule
Emp. Form.:
C21H28N4O2
Mol. Mass.:
368.4726
SMILES:
CCC(CC)Nc1cc(C)nc2c(c(C)nn12)-c1ccc(OC)cc1OC |(12.35,-6.41,;12.32,-7.95,;13.63,-8.75,;14.98,-8.03,;15.03,-6.49,;13.59,-10.29,;12.23,-11.03,;12.18,-12.57,;10.82,-13.32,;10.78,-14.85,;9.5,-12.5,;9.55,-10.95,;8.45,-9.88,;9.12,-8.49,;8.38,-7.14,;10.64,-8.7,;10.92,-10.22,;6.94,-10.14,;6.42,-11.59,;4.9,-11.87,;3.9,-10.68,;2.4,-10.96,;1.87,-12.41,;4.43,-9.24,;5.95,-8.98,;6.47,-7.51,;5.49,-6.34,)|
Structure:
Search PDB for entries with ligand similarity: