Target
Corticotropin-releasing factor receptor 1
Ligand
BDBM50148900
Substrate
n/a
Meas. Tech.
ChEBML_51104
Ki
>10000±n/a nM
Citation
 Chen, CWilcoxen, KMHuang, CQMcCarthy, JRChen, TGrigoriadis, DE Optimization of 3-phenylpyrazolo[1,5-a]pyrimidines as potent corticotropin-releasing factor-1 antagonists with adequate lipophilicity and water solubility. Bioorg Med Chem Lett 14:3669-73 (2004) [PubMed]  Article
Target
Name:
Corticotropin-releasing factor receptor 1
Synonyms:
CRF-R | CRF-R2 Alpha | CRF1 | CRH-R 1 | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1
Type:
Enzyme
Mol. Mass.:
50744.31
Organism:
Homo sapiens (Human)
Description:
P34998
Residue:
444
Sequence:
MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
  
Inhibitor
Name:
BDBM50148900
Synonyms:
CHEMBL334239 | {3-[4-(2-Dimethylamino-ethoxy)-phenyl]-2,5-dimethyl-3H-pyrazolo[1,5-a]pyrimidin-7-yl}-dipropyl-amine
Type:
Small organic molecule
Emp. Form.:
C24H35N5O
Mol. Mass.:
409.5676
SMILES:
CCCN(CCC)c1cc(C)nc2c(c(C)nn12)-c1ccc(OCCN(C)C)cc1
Structure:
Search PDB for entries with ligand similarity: