Reaction Details Report a problem with these data
Target
POU domain, class 3, transcription factor 3
Ligand
BDBM50149547
Substrate
n/a
Meas. Tech.
ChEMBL_305968 (CHEMBL832954)
IC50
124000±n/a nM
Citation
 Ji, T; Lee, M; Pruitt, SC; Hangauer, DG Privileged scaffolds for blocking protein-protein interactions: 1,4-disubstituted naphthalene antagonists of transcription factor complex HOX-PBX/DNA. Bioorg Med Chem Lett 14:3875-9 (2004) [PubMed]  Article 
Target
Name:
POU domain, class 3, transcription factor 3
Synonyms:
BRN1 | Homeobox protein Brn-1 | OTF8 | PO3F3_HUMAN | POU3F3
Type:
PROTEIN
Mol. Mass.:
50342.98
Organism:
Homo sapiens (Human)
Description:
ChEMBL_305968
Residue:
500
Sequence:
MATAASNPYLPGNSLLAAGSIVHSDAAGAGGGGGGGGGGGGGGAGGGGGGMQPGSAAVTSGAYRGDPSSVKMVQSDFMQGAMAASNGGHMLSHAHQWVTALPHAAAAAAAAAAAAVEASSPWSGSAVGMAGSPQQPPQPPPPPPQGPDVKGGAGRDDLHAGTALHHRGPPHLGPPPPPPHQGHPGGWGAAAAAAAAAAAAAAAAHLPSMAGGQQPPPQSLLYSQPGGFTVNGMLSAPPGPGGGGGGAGGGAQSLVHPGLVRGDTPELAEHHHHHHHHAHPHPPHPHHAQGPPHHGGGGGGAGPGLNSHDPHSDEDTPTSDDLEQFAKQFKQRRIKLGFTQADVGLALGTLYGNVFSQTTICRFEALQLSFKNMCKLKPLLNKWLEEADSSTGSPTSIDKIAAQGRKRKKRTSIEVSVKGALESHFLKCPKPSAQEITNLADSLQLEKEVVRVWFCNRRQKEKRMTPPGIQQQTPDDVYSQVGTVSADTPPPHHGLQTSVQ
  
Inhibitor
Name:
BDBM50149547
Synonyms:
4-[(4-Hydroxy-phenylcarbamoyl)-methoxy]-naphthalene-1-carboxylic acid (3-fluoro-phenyl)-amide | CHEMBL182765
Type:
Small organic molecule
Emp. Form.:
C25H19FN2O4
Mol. Mass.:
430.4278
SMILES:
Oc1ccc(NC(=O)COc2ccc(C(=O)Nc3cccc(F)c3)c3ccccc23)cc1
Structure:
Search PDB for entries with ligand similarity: