Reaction Details Report a problem with these data
Target
POU domain, class 3, transcription factor 2
Ligand
BDBM50149565
Substrate
n/a
Meas. Tech.
ChEMBL_305969 (CHEMBL832955)
IC50
204000±n/a nM
Citation
 Ji, T; Lee, M; Pruitt, SC; Hangauer, DG Privileged scaffolds for blocking protein-protein interactions: 1,4-disubstituted naphthalene antagonists of transcription factor complex HOX-PBX/DNA. Bioorg Med Chem Lett 14:3875-9 (2004) [PubMed]  Article 
Target
Name:
POU domain, class 3, transcription factor 2
Synonyms:
BRN2 | Homeobox protein Brn-2 | OCT7 | OTF7 | PO3F2_HUMAN | POU3F2
Type:
PROTEIN
Mol. Mass.:
46908.80
Organism:
Homo sapiens (Human)
Description:
ChEMBL_305969
Residue:
443
Sequence:
MATAASNHYSLLTSSASIVHAEPPGGMQQGAGGYREAQSLVQGDYGALQSNGHPLSHAHQWITALSHGGGGGGGGGGGGGGGGGGGGGDGSPWSTSPLGQPDIKPSVVVQQGGRGDELHGPGALQQQHQQQQQQQQQQQQQQQQQQQQQRPPHLVHHAANHHPGPGAWRSAAAAAHLPPSMGASNGGLLYSQPSFTVNGMLGAGGQPAGLHHHGLRDAHDEPHHADHHPHPHSHPHQQPPPPPPPQGPPGHPGAHHDPHSDEDTPTSDDLEQFAKQFKQRRIKLGFTQADVGLALGTLYGNVFSQTTICRFEALQLSFKNMCKLKPLLNKWLEEADSSSGSPTSIDKIAAQGRKRKKRTSIEVSVKGALESHFLKCPKPSAQEITSLADSLQLEKEVVRVWFCNRRQKEKRMTPPGGTLPGAEDVYGGSRDTPPHHGVQTPVQ
  
Inhibitor
Name:
BDBM50149565
Synonyms:
4-[(2,2,2-Trifluoro-ethylcarbamoyl)-methoxy]-naphthalene-1-carboxylic acid (3-fluoro-phenyl)-amide | CHEMBL363937
Type:
Small organic molecule
Emp. Form.:
C21H16F4N2O3
Mol. Mass.:
420.357
SMILES:
Fc1cccc(NC(=O)c2ccc(OCC(=O)NCC(F)(F)F)c3ccccc23)c1
Structure:
Search PDB for entries with ligand similarity: