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Target
Cathepsin B
Ligand
BDBM50150525
Substrate
n/a
Meas. Tech.
ChEMBL_304815 (CHEMBL827904)
IC50
93±n/a nM
Citation
 Robichaud, J; Bayly, C; Oballa, R; Prasit, P; Mellon, C; Falgueyret, JP; Percival, MD; Wesolowski, G; Rodan, SB Rational design of potent and selective NH-linked aryl/heteroaryl cathepsin K inhibitors. Bioorg Med Chem Lett 14:4291-5 (2004) [PubMed]  Article 
Target
Name:
Cathepsin B
Synonyms:
APP secretase | APPS | CATB_HUMAN | CPSB | CTSB | Cathepsin B heavy chain | Cathepsin B light chain | Cathepsin B1
Type:
Enzyme
Mol. Mass.:
37819.69
Organism:
Homo sapiens (Human)
Description:
gi_63102437
Residue:
339
Sequence:
MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCGTFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSWNTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
  
Inhibitor
Name:
BDBM50150525
Synonyms:
4-Methyl-2-(4''-piperazin-1-yl-biphenyl-3-ylamino)-pentanoic acid cyanomethyl-amide | CHEMBL185431
Type:
Small organic molecule
Emp. Form.:
C24H31N5O
Mol. Mass.:
405.5358
SMILES:
CC(C)C[C@H](Nc1cccc(c1)-c1ccc(cc1)N1CCNCC1)C(=O)NCC#N
Structure:
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