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Target
Cathepsin K
Ligand
BDBM50150535
Substrate
n/a
Meas. Tech.
ChEMBL_305167 (CHEMBL832757)
IC50
433±n/a nM
Citation
 Robichaud, J; Bayly, C; Oballa, R; Prasit, P; Mellon, C; Falgueyret, JP; Percival, MD; Wesolowski, G; Rodan, SB Rational design of potent and selective NH-linked aryl/heteroaryl cathepsin K inhibitors. Bioorg Med Chem Lett 14:4291-5 (2004) [PubMed]  Article 
Target
Name:
Cathepsin K
Synonyms:
CATK_RABIT | CTSK
Type:
Enzyme
Mol. Mass.:
36879.51
Organism:
Oryctolagus cuniculus (rabbit)
Description:
n/a
Residue:
329
Sequence:
MWGLKVLLLPVVSFALHPEEILDTQWELWKKTYSKQYNSKVDEISRRLIWEKNLKHISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPPSRSHSNDTLYIPDWEGRTPDSIDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENYGCGGGYMTNAFQYVQRNRGIDSEDAYPYVGQDESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDENCSSDNVNHAVLAVGYGIQKGNKHWIIKNSWGESWGNKGYILMARNKNNACGIANLASFPKM
  
Inhibitor
Name:
BDBM50150535
Synonyms:
2-(2-Bromo-phenylsulfanyl)-4-methyl-pentanoic acid cyanomethyl-amide | CHEMBL185305
Type:
Small organic molecule
Emp. Form.:
C14H17BrN2OS
Mol. Mass.:
341.267
SMILES:
CC(C)CC(Sc1ccccc1Br)C(=O)NCC#N
Structure:
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