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Target
Prostaglandin G/H synthase 2
Ligand
BDBM50151768
Substrate
n/a
Meas. Tech.
ChEMBL_306195 (CHEMBL830989)
IC50
130±n/a nM
Citation
 Campbell, JA; Bordunov, V; Broka, CA; Browner, MF; Kress, JM; Mirzadegan, T; Ramesha, C; Sanpablo, BF; Stabler, R; Takahara, P; Villasenor, A; Walker, KA; Wang, JH; Welch, M; Weller, P Rational design of 6-methylsulfonylindoles as selective cyclooxygenase-2 inhibitors. Bioorg Med Chem Lett 14:4741-5 (2004) [PubMed]  Article 
Target
Name:
Prostaglandin G/H synthase 2
Synonyms:
COX2 | Cyclooxygenase | Cyclooxygenase 2 (COX-2) | Cyclooxygenase-2 | Cyclooxygenase-2 (COX-2 AA) | Cyclooxygenase-2 (COX-2 AEA) | Cyclooxygenase-2 (COX-2) | PGH synthase 2 | PGH2_HUMAN | PGHS-2 | PHS II | PTGS2 | Prostaglandin E synthase/G/H synthase 2 | Prostaglandin H2 synthase 2 | Prostaglandin-endoperoxide synthase 2
Type:
Enzyme
Mol. Mass.:
69003.89
Organism:
Homo sapiens (Human)
Description:
Recombinant Cox-2 provided by Cayman (Cayman Chemical Co.,Ann Arbor, MI).
Residue:
604
Sequence:
MLARALLLCAVLALSHTANPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENCSTPEFLTRIKLFLKPTPNTVHYILTHFKGFWNVVNNIPFLRNAIMSYVLTSRSHLIDSPPTYNADYGYKSWEAFSNLSYYTRALPPVPDDCPTPLGVKGKKQLPDSNEIVEKLLLRRKFIPDPQGSNMMFAFFAQHFTHQFFKTDHKRGPAFTNGLGHGVDLNHIYGETLARQRKLRLFKDGKMKYQIIDGEMYPPTVKDTQAEMIYPPQVPEHLRFAVGQEVFGLVPGLMMYATIWLREHNRVCDVLKQEHPEWGDEQLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPELLFNKQFQYQNRIAAEFNTLYHWHPLLPDTFQIHDQKYNYQQFIYNNSILLEHGITQFVESFTRQIAGRVAGGRNVPPAVQKVSQASIDQSRQMKYQSFNEYRKRFMLKPYESFEELTGEKEMSAELEALYGDIDAVELYPALLVEKPRPDAIFGETMVEVGAPFSLKGLMGNVICSPAYWKPSTFGGEVGFQIINTASIQSLICNNVKGCPFTSFSVPDPELIKTVTINASSSRSGLDDINPTVLLKERSTEL
  
Inhibitor
Name:
BDBM50151768
Synonyms:
3-(2-Chloro-phenylsulfanyl)-6-methanesulfonyl-1H-indole-2-carbonitrile | CHEMBL183294
Type:
Small organic molecule
Emp. Form.:
C16H11ClN2O2S2
Mol. Mass.:
362.854
SMILES:
CS(=O)(=O)c1ccc2c(Sc3ccccc3Cl)c([nH]c2c1)C#N
Structure:
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