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Target
Mitogen-activated protein kinase 14
Ligand
BDBM50153835
Substrate
n/a
Meas. Tech.
ChEMBL_305841 (CHEMBL829582)
IC50
180±n/a nM
Citation
 Brown, DS; Belfield, AJ; Brown, GR; Campbell, D; Foubister, A; Masters, DJ; Pike, KG; Snelson, WL; Wells, SL A novel series of p38 MAP kinase inhibitors for the potential treatment of rheumatoid arthritis. Bioorg Med Chem Lett 14:5383-7 (2004) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM50153835
Synonyms:
1-(3-dimethylaminophenylcarboxamido)-3-(4-hydroxyphenylcarboxamido)-4-methylbenzene | 3-(dimethylamino)-N-(3-(4-hydroxybenzamido)-4-methylphenyl)benzamide | CHEMBL186526 | N-[5-(3-dimethylaminobenzamido)-2-methylphenyl]-4-hydroxybenzamide | ZM-336372
Type:
Small organic molecule
Emp. Form.:
C23H23N3O3
Mol. Mass.:
389.447
SMILES:
CN(C)c1cccc(c1)C(=O)Nc1ccc(C)c(NC(=O)c2ccc(O)cc2)c1
Structure:
Search PDB for entries with ligand similarity: