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TargetCathepsin L1
LigandBDBM50156086
Substrate/Competitorn/a
Meas. Tech.ChEMBL_306405
IC50 44±n/a nM
Citation Altmann, ECowan-Jacob, SWMissbach, M Novel purine nitrile derived inhibitors of the cysteine protease cathepsin K. J Med Chem47:5833-6 (2004) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cathepsin L1
Name:Cathepsin (L and K)
Synonyms:Cathepsin (L and K) | Cathepsin L | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein
Type:Enzyme
Mol. Mass.:37557.19
Organism:Homo sapiens (Human)
Description:Purchased from Calbiochem (San Diego, CA).
Residue:333
Sequence:
MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIE
LHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDW
REKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNG
GLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVA
TVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKN
SWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50156086
NameBDBM50156086
Synonyms:9-CYCLOPENTYL-6-[2-(3-IMIDAZOL-1-YL-PROPOXY)-PHENYLAMINO]-9H-PURINE-2-CARBONITRILE | CHEMBL188865
TypeSmall organic molecule
Emp. Form.C23H24N8O
Mol. Mass.428.4897
SMILESN#Cc1nc(Nc2ccccc2OCCCn2ccnc2)c2ncn(C3CCCC3)c2n1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a