Reaction Details Report a problem with these data
Target
Thyrotropin-releasing hormone receptor
Ligand
BDBM50156181
Substrate
n/a
Meas. Tech.
ChEMBL_303571 (CHEMBL828971)
Ki
>10000±n/a nM
Citation
Prokai, L; Prokai-Tatrai, K; Zharikova, AD; Nguyen, V; Perjesi, P; Stevens, SM Centrally acting and metabolically stable thyrotropin-releasing hormone analogues by replacement of histidine with substituted pyridinium. J Med Chem 47:6025-33 (2004) [PubMed] Article
More Info.:
Target
Name:
Thyrotropin-releasing hormone receptor
Synonyms:
TRH-R | TRHR_RAT | Thyroliberin receptor | Trhr
Type:
PROTEIN
Mol. Mass.:
46618.79
Organism:
Rattus norvegicus
Description:
ChEMBL_303571
Residue:
412
Sequence:
MENETVSELNQTELPPQVAVALEYQVVTILLVVVICGLGIVGNIMVVLVVMRTKHMRTATNCYLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFTIERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSIYCMLWFFLLDLNISTYKDAIVISCGYKISRNYYSPIYLMDFGVFYVMPMILATVLYGFIARILFLNPIPSDPKENSKTWKNDSTHQNKNMNLNTTNRCFNSTVSSRKQVTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENWFLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKPTEKAANYSVALNYSVIKESDRFSTELDDITVTDTYVSTTKVSFDDTCLASEKNGPSSCTYGYSLTAKQEKI
Inhibitor
Name:
BDBM50156181
Synonyms:
3-carbamoyl-1-{3-(2-carbamoyl-pyrrolidin-1-yl)-3-oxo-2-[(5-oxo-pyrrolidine-2-carbonyl)-amino]-propyl}-pyridinium; Trifluoro-acetate | CHEMBL370700
Type:
Small organic molecule
Emp. Form.:
C19H25N6O5
Mol. Mass.:
417.4385
SMILES:
NC(=O)C1CCCN1C(=O)C(C[n+]1cccc(c1)C(N)=O)NC(=O)C1CCC(=O)N1