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Target
Cathepsin B
Ligand
BDBM50159149
Substrate
n/a
Meas. Tech.
ChEMBL_311968 (CHEMBL834385)
IC50
>1000000±n/a nM
Citation
 Aubin, S; Martin, B; Delcros, JG; Arlot-Bonnemains, Y; Baudy-Floc'h, M Retro hydrazino-azapeptoids as peptidomimetics of proteasome inhibitors. J Med Chem 48:330-4 (2005) [PubMed]  Article 
Target
Name:
Cathepsin B
Synonyms:
APP secretase | APPS | CATB_HUMAN | CPSB | CTSB | Cathepsin B heavy chain | Cathepsin B light chain | Cathepsin B1
Type:
Enzyme
Mol. Mass.:
37819.69
Organism:
Homo sapiens (Human)
Description:
gi_63102437
Residue:
339
Sequence:
MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCGTFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSWNTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
  
Inhibitor
Name:
BDBM50159149
Synonyms:
CHEMBL179042 | Peptidyl boronic acid derivative
Type:
Small organic molecule
Emp. Form.:
C28H33BN4O5
Mol. Mass.:
516.396
SMILES:
CC(C)CN(NC(=O)OCc1ccccc1)C(=O)CN(Cc1ccccc1)N=Cc1cccc(c1)B(O)O |w:28.30|
Structure:
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