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Target
Tubulin beta-1 chain
Ligand
BDBM50159293
Substrate
n/a
Meas. Tech.
ChEMBL_305199 (CHEMBL832453)
IC50
>100000±n/a nM
Citation
 Ducki, S; Mackenzie, G; Lawrence, NJ; Snyder, JP Quantitative structure-activity relationship (5D-QSAR) study of combretastatin-like analogues as inhibitors of tubulin assembly. J Med Chem 48:457-65 (2005) [PubMed]  Article 
Target
Name:
Tubulin beta-1 chain
Synonyms:
TBB1_HUMAN | TUBB1
Type:
PROTEIN
Mol. Mass.:
50311.77
Organism:
Homo sapiens (Human)
Description:
ChEMBL_305173
Residue:
451
Sequence:
MREIVHIQIGQCGNQIGAKFWEMIGEEHGIDLAGSDRGASALQLERISVYYNEAYGRKYVPRAVLVDLEPGTMDSIRSSKLGALFQPDSFVHGNSGAGNNWAKGHYTEGAELIENVLEVVRHESESCDCLQGFQIVHSLGGGTGSGMGTLLMNKIREEYPDRIMNSFSVMPSPKVSDTVVEPYNAVLSIHQLIENADACFCIDNEALYDICFRTLKLTTPTYGDLNHLVSLTMSGITTSLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTAQGSQQYRALSVAELTQQMFDARNTMAACDLRRGRYLTVACIFRGKMSTKEVDQQLLSVQTRNSSCFVEWIPNNVKVAVCDIPPRGLSMAATFIGNNTAIQEIFNRVSEHFSAMFKRKAFVHWYTSEGMDINEFGEAENNIHDLVSEYQQFQDAKAVLEEDEEVTEEAEMEPEDKGH
  
Inhibitor
Name:
BDBM50159293
Synonyms:
(E)-3-(3,4,5-Trihydroxy-phenyl)-1-(2,3,4-trimethoxy-phenyl)-propenone | CHEMBL192276
Type:
Small organic molecule
Emp. Form.:
C18H18O7
Mol. Mass.:
346.3313
SMILES:
COc1ccc(C(=O)\C=C\c2cc(O)c(O)c(O)c2)c(OC)c1OC
Structure:
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