Reaction Details Report a problem with these data
Target
Melanocortin receptor 4
Ligand
BDBM50162725
Substrate
n/a
Meas. Tech.
ChEMBL_310206 (CHEMBL833811)
EC50
65±n/a nM
Citation
 Fotsch, C; Han, N; Arasasingham, P; Bo, Y; Carmouche, M; Chen, N; Davis, J; Goldberg, MH; Hale, C; Hsieh, FY; Kelly, MG; Liu, Q; Norman, MH; Smith, DM; Stec, M; Tamayo, N; Xi, N; Xu, S; Bannon, AW; Baumgartner, JW Melanocortin subtype-4 receptor agonists containing a piperazine core with substituted aryl sulfonamides. Bioorg Med Chem Lett 15:1623-7 (2005) [PubMed]  Article 
Target
Name:
Melanocortin receptor 4
Synonyms:
MC4-R | MC4R | MC4R_HUMAN | Melanocortin MC4 | Melanocortin receptor 4 (MC-4) | Melanocortin receptor 4 (MC4-R) | Melanocortin receptor 4 (MC4R)
Type:
Enzyme
Mol. Mass.:
36949.50
Organism:
Homo sapiens (Human)
Description:
P32245
Residue:
332
Sequence:
MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVSGILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIICCYPLGGLCDLSSRY
  
Inhibitor
Name:
BDBM50162725
Synonyms:
(S)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid {(R)-1-(4-chloro-benzyl)-2-oxo-2-[4-(2-phenylmethanesulfonylamino-phenyl)-piperazin-1-yl]-ethyl}-amide | CHEMBL180854
Type:
Small organic molecule
Emp. Form.:
C36H38ClN5O4S
Mol. Mass.:
672.236
SMILES:
Clc1ccc(C[C@@H](NC(=O)[C@@H]2Cc3ccccc3CN2)C(=O)N2CCN(CC2)c2ccccc2NS(=O)(=O)Cc2ccccc2)cc1
Structure:
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