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Target
Follicle-stimulating hormone receptor
Ligand
BDBM50410306
Substrate
n/a
Meas. Tech.
ChEMBL_312853 (CHEMBL874932)
IC50
5±n/a nM
Citation
 van Straten, NC; van Berkel, TH; Demont, DR; Karstens, WJ; Merkx, R; Oosterom, J; Schulz, J; van Someren, RG; Timmers, CM; van Zandvoort, PM Identification of substituted 6-amino-4-phenyltetrahydroquinoline derivatives: potent antagonists for the follicle-stimulating hormone receptor. J Med Chem 48:1697-700 (2005) [PubMed]  Article 
Target
Name:
Follicle-stimulating hormone receptor
Synonyms:
FSH-R | FSHR | FSHR_HUMAN | Follicle stimulating hormone receptor | Follicle-stimulating hormone receptor | Follitropin receptor | LGR1
Type:
PROTEIN
Mol. Mass.:
78273.21
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1351769
Residue:
695
Sequence:
MALLLVSLLAFLSLGSGCHHRICHCSNRVFLCQESKVTEIPSDLPRNAIELRFVLTKLRVIQKGAFSGFGDLEKIEISQNDVLEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQNLPNLQYLLISNTGIKHLPDVHKIHSLQKVLLDIQDNINIHTIERNSFVGLSFESVILWLNKNGIQEIHNCAFNGTQLDELNLSDNNNLEELPNDVFHGASGPVILDISRTRIHSLPSYGLENLKKLRARSTYNLKKLPTLEKLVALMEASLTYPSHCCAFANWRRQISELHPICNKSILRQEVDYMTQARGQRSSLAEDNESSYSRGFDMTYTEFDYDLCNEVVDVTCSPKPDAFNPCEDIMGYNILRVLIWFISILAITGNIIVLVILTTSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDIHTKSQYHNYAIDWQTGAGCDAAGFFTVFASELSVYTLTAITLERWHTITHAMQLDCKVQLRHAASVMVMGWIFAFAAALFPIFGISSYMKVSICLPMDIDSPLSQLYVMSLLVLNVLAFVVICGCYIHIYLTVRNPNIVSSSSDTRIAKRMAMLIFTDFLCMAPISFFAISASLKVPLITVSKAKILLVLFHPINSCANPFLYAIFTKNFRRDFFILLSKCGCYEMQAQIYRTETSSTVHNTHPRNGHCSSAPRVTNGSTYILVPLSHLAQN
  
Inhibitor
Name:
BDBM50410306
Synonyms:
CHEMBL436481
Type:
Small organic molecule
Emp. Form.:
C34H34N2O2
Mol. Mass.:
502.646
SMILES:
CC(=O)N1c2cc(C)c(NC(=O)c3ccc(cc3)-c3ccccc3)cc2C(C)(CC1(C)C)c1ccccc1
Structure:
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