Reaction Details Report a problem with these data
Target
P04972/P11541/P16586/P22571/P23439/Q95142
Ligand
BDBM50165816
Substrate
n/a
Meas. Tech.
ChEMBL_304733 (CHEMBL829333)
IC50
590±n/a nM
Citation
 Feixas, J; Giovannoni, MP; Vergelli, C; Gavaldà, A; Cesari, N; Graziano, A; Dal Piaz, V New pyrazolo[1',5':1,6]pyrimido[4,5-d]pyridazin-4(3H)-ones as potent and selective PDE5 inhibitors. Bioorg Med Chem Lett 15:2381-4 (2005) [PubMed]  Article 
Target
Name:
P04972/P11541/P16586/P22571/P23439/Q95142
Synonyms:
Phosphodiesterase 6
Type:
n/a
Mol. Mass.:
n/a
Description:
ASSAY_ID of ChEMBL is 155381
Components:
This complex has 6 components.
Component 1
Name:
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
Synonyms:
CNRG_BOVIN | GMP-PDE gamma | PDE6G | PDEG
Type:
PROTEIN
Mol. Mass.:
9674.16
Organism:
Bos taurus
Description:
ChEMBL_104859
Residue:
87
Sequence:
MNLEPPKAEIRSATRVMGGPVTPRKGPPKFKQRQTRQFKSKPPKKGVQGFGDDIPGMEGLGTDITVICPWEAFNHLELHELAQYGII
  
Component 2
Name:
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'
Synonyms:
PDE V-C1 | PDE6C | PDE6C_BOVIN | PDEA2 | cGMP phosphodiesterase 6C
Type:
PROTEIN
Mol. Mass.:
98783.85
Organism:
Bos taurus
Description:
ChEMBL_104859
Residue:
855
Sequence:
MGEISQETVEKYLEANPQFAKEYFNRKLQVEVPSGGAQAPASASFPGRTLAEEAALYLELLEVLLEEAGSVELAAHRALQRLAQLLQADRCSMFLCRARNGTPEVASKLLDVTPTSKFEDNLVVPDREAVFPLDVGIVGWVAHTKKTFNVPDVKKNSHFSDFMDKQTGYVTRNLLATPIVMGKEVLAVFMAVNKVDASEFSKQDEEVFSKYLSFVSIILKLHHTNYLYNIESRRSQILMWSANKVFEELTDVERQFHKALYTVRTYLNCERYSIGLLDMTKEKEFYDEWPVKLGEVEPYKGPKTPDGREVIFYKIIDYILHGKEEIKVIPTPPMDHWTLISGLPTYVAENGFICNMLNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEYDEHIAETLTQFLGWSLLNTDTYEKMNKLENRKDIAQEMLMNHTKATPDEIKSILKFKEKLNIDVIEDCEEKQLVTILKEDLPDPRTADLYEFRFRHLPITEHELIKCGLRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQYETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEKMETEEEAIKYVTIDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALLVANEFWEQGDLERTVLQQQPIPMMDRNKKDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLNGLQNNRVEWKSLADEYDEKMKVIEEMKKQEEGNTTEKAVEDSGGGGDDKKSKTCLML
  
Component 3
Name:
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha
Synonyms:
PDE6A | PDE6A_BOVIN | PDEA | Phosphodiesterase 6 | Phosphodiesterase 6A
Type:
Enzyme
Mol. Mass.:
99320.22
Organism:
Bos taurus (Bovine)
Description:
P11541
Residue:
859
Sequence:
MGEVTAEEVEKFLDSNVSFAKQYYNLRYRAKVISDLLGPREAAVDFSNYHALNSVEESEIIFDLLRDFQDNLQAEKCVFNVMKKLCFLLQADRMSLFMYRARNGIAELATRLFNVHKDAVLEECLVAPDSEIVFPLDMGVVGHVALSKKIVNVPNTEEDEHFCDFVDTLTEYQTKNILASPIMNGKDVVAIIMVVNKVDGPHFTENDEEILLKYLNFANLIMKVFHLSYLHNCETRRGQILLWSGSKVFEELTDIERQFHKALYTVRAFLNCDRYSVGLLDMTKQKEFFDVWPVLMGEAPPYAGPRTPDGREINFYKVIDYILHGKEDIKVIPNPPPDHWALVSGLPTYVAQNGLICNIMNAPSEDFFAFQKEPLDESGWMIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDEMDETLMESLTQFLGWSVLNPDTYELMNKLENRKDIFQDMVKYHVKCDNEEIQTILKTREVYGKEPWECEEEELAEILQGELPDADKYEINKFHFSDLPLTELELVKCGIQMYYELKVVDKFHIPQEALVRFMYSLSKGYRRITYHNWRHGFNVGQTMFSLLVTGKLKRYFTDLEALAMVTAAFCHDIDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKTLLRDESLNIFQNLNRRQHEHAIHMMDIAIIATDLALYFKKRTMFQKIVDQSKTYETQQEWTQYMMLDQTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLQQNPIPMMDRNKADELPKLQVGFIDFVCTFVYKEFSRFHEEITPMLDGITNNRKEWKALADEYETKMKGLEEEKQKQQAANQAAAGSQHGGKQPGGGPASKSCCVQ
  
Component 4
Name:
Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
Synonyms:
CNCG_BOVIN | GMP-PDE gamma | PDE6H
Type:
PROTEIN
Mol. Mass.:
9106.39
Organism:
Bos taurus
Description:
ChEMBL_104859
Residue:
83
Sequence:
MSDNTVLAPPTSNQGPTTPRKGPPKFKQRQTRQFKSKPPKKGVKGFGDDIPGMEGLGTDITVICPWEAFSHLELHELAQFGII
  
Component 5
Name:
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
Synonyms:
GMP-PDE delta | PDE6D | PDE6D_BOVIN
Type:
PROTEIN
Mol. Mass.:
17388.28
Organism:
Bos taurus
Description:
ChEMBL_104859
Residue:
150
Sequence:
MSAKDERAREILRGFKLNWMNLRDAETGKILWQGTEDLSVPGVEHEARVPKKILKCKAVSRELNFSSAEQMEKFRLEQKVYFKGQCLEEWFFEFGFVIPNSTNTWQSLIEAAPESQMMPASVLTGNVIIETKFFDDDLLVSTSRVRLFYV
  
Component 6
Name:
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta
Synonyms:
GMP-PDE beta | PDE6B | PDE6B_BOVIN | PDEB
Type:
PROTEIN
Mol. Mass.:
98307.54
Organism:
Bos taurus
Description:
ChEMBL_104859
Residue:
853
Sequence:
MSLSEGQVHRFLDQNPGFADQYFGRKLSPEDVANACEDGCPEGCTSFRELCQVEESAALFELVQDMQENVNMERVVFKILRRLCSILHADRCSLFMYRQRNGVAELATRLFSVQPDSVLEDCLVPPDSEIVFPLDIGVVGHVAQTKKMVNVQDVMECPHFSSFADELTDYVTRNILATPIMNGKDVVAVIMAVNKLDGPCFTSEDEDVFLKYLNFGTLNLKIYHLSYLHNCETRRGQVLLWSANKVFEELTDIERQFHKAFYTVRAYLNCDRYSVGLLDMTKEKEFFDVWPVLMGEAQAYSGPRTPDGREILFYKVIDYILHGKEDIKVIPSPPADHWALASGLPTYVAESGFICNIMNAPADEMFNFQEGPLDDSGWIVKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDEQDEVLMESLTQFLGWSVLNTDTYDKMNKLENRKDIAQDMVLYHVRCDREEIQLILPTRERLGKEPADCEEDELGKILKEVLPGPAKFDIYEFHFSDLECTELELVKCGIQMYYELGVVRKFQIPQEVLVRFLFSVSKGYRRITYHNWRHGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKFLLSEETLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRTMFQKIVDESKNYEDRKSWVEYLSLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMMDRNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWKALADEYEAKVKALEEDQKKETTAKKVGTEICNGGPAPRSSTCRIL
  
Inhibitor
Name:
BDBM50165816
Synonyms:
3-(7-Benzyl-9-methyl-6-oxo-2-phenyl-6,7-dihydro-3,3a,5,7,8-pentaaza-cyclopenta[a]naphthalen-4-yl)-propionic acid | CHEMBL195830
Type:
Small organic molecule
Emp. Form.:
C25H21N5O3
Mol. Mass.:
439.4659
SMILES:
Cc1nn(Cc2ccccc2)c(=O)c2nc(CCC(O)=O)n3nc(cc3c12)-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: