Reaction Details Report a problem with these data
Target
alpha-1,2-Mannosidase
Ligand
BDBM50168993
Substrate
n/a
Meas. Tech.
ChEMBL_302738 (CHEMBL838685)
Ki
7400±n/a nM
Citation
 Fiaux, H; Popowycz, F; Favre, S; Schütz, C; Vogel, P; Gerber-Lemaire, S; Juillerat-Jeanneret, L Functionalized pyrrolidines inhibit alpha-mannosidase activity and growth of human glioblastoma and melanoma cells. J Med Chem 48:4237-46 (2005) [PubMed]  Article 
Target
Name:
alpha-1,2-Mannosidase
Synonyms:
Alpha-mannosidase
Type:
PROTEIN
Mol. Mass.:
65344.50
Organism:
Glycine max
Description:
ChEMBL_32380
Residue:
578
Sequence:
MARGSRSVGSSSSKWRYCNPSYYLKRPKRLALLFIVFVCVSFVFWDRQTLVREHQVEISELQKEVTDLKNLVDDLNNKQGGTSGKTDLGRKATKSSKDVLDDPIDIERREKVKEAMLHAWGSYEKYAWGQDELQPQSKNGVNSFGGLGATLIDSLDTLYIMGLNEQFQKAREWVANSLDFNKDYEASVFETTIRVVGGLLSAYDLSGDKVFLDKAIEIADRLLPAWNTPTGIPYNIINLSHGRAHNPSWTGGESILADSGTEQLEFIVLSQRTGDLKYQQKVENVIAQLNKTFPDDGLLPIYINPHSGAAGYSPITFGAMGDSFYEYLLKVWIQGNKTSSIKHYRDMWEKSMKGLSSLIRRSTPSSFTYICEKNGGSLTDKMDELACFAPGMIALGSFGYSAADDSQKFLSLAEELAWTCYNFYQSTPTKLAGENYFFHSGQDMSVGTSWNILRPETVESLFYLWRLTGNKTYQEWGWNIFQAFEKNSRIESGYVGLKDVNSGVKDNMMQSFFLAETLKYFYLLFSPSSVISLDEWVFNTEAHPLRIVTRHEEGLVKNLNEKQKPFSRIGGRKEGRSG
  
Inhibitor
Name:
BDBM50168993
Synonyms:
(2R,3R,4S)-2-(Benzylamino-methyl)-pyrrolidine-3,4-diol | CHEMBL363475
Type:
Small organic molecule
Emp. Form.:
C12H18N2O2
Mol. Mass.:
222.2835
SMILES:
O[C@H]1CN[C@H](CNCc2ccccc2)[C@H]1O
Structure:
Search PDB for entries with ligand similarity: