Reaction Details Report a problem with these data
Target
alpha-1,2-Mannosidase
Ligand
BDBM50168991
Substrate
n/a
Meas. Tech.
ChEMBL_305169 (CHEMBL832759)
IC50
4200±n/a nM
Citation
 Fiaux, H; Popowycz, F; Favre, S; Schütz, C; Vogel, P; Gerber-Lemaire, S; Juillerat-Jeanneret, L Functionalized pyrrolidines inhibit alpha-mannosidase activity and growth of human glioblastoma and melanoma cells. J Med Chem 48:4237-46 (2005) [PubMed]  Article 
Target
Name:
alpha-1,2-Mannosidase
Synonyms:
Alpha-mannosidase
Type:
PROTEIN
Mol. Mass.:
65344.50
Organism:
Glycine max
Description:
ChEMBL_32380
Residue:
578
Sequence:
MARGSRSVGSSSSKWRYCNPSYYLKRPKRLALLFIVFVCVSFVFWDRQTLVREHQVEISELQKEVTDLKNLVDDLNNKQGGTSGKTDLGRKATKSSKDVLDDPIDIERREKVKEAMLHAWGSYEKYAWGQDELQPQSKNGVNSFGGLGATLIDSLDTLYIMGLNEQFQKAREWVANSLDFNKDYEASVFETTIRVVGGLLSAYDLSGDKVFLDKAIEIADRLLPAWNTPTGIPYNIINLSHGRAHNPSWTGGESILADSGTEQLEFIVLSQRTGDLKYQQKVENVIAQLNKTFPDDGLLPIYINPHSGAAGYSPITFGAMGDSFYEYLLKVWIQGNKTSSIKHYRDMWEKSMKGLSSLIRRSTPSSFTYICEKNGGSLTDKMDELACFAPGMIALGSFGYSAADDSQKFLSLAEELAWTCYNFYQSTPTKLAGENYFFHSGQDMSVGTSWNILRPETVESLFYLWRLTGNKTYQEWGWNIFQAFEKNSRIESGYVGLKDVNSGVKDNMMQSFFLAETLKYFYLLFSPSSVISLDEWVFNTEAHPLRIVTRHEEGLVKNLNEKQKPFSRIGGRKEGRSG
  
Inhibitor
Name:
BDBM50168991
Synonyms:
(2R,3S,4R,5R)-2-Hydroxymethyl-5-[((R)-2-hydroxy-1-phenyl-ethylamino)-methyl]-pyrrolidine-3,4-diol | CHEMBL425364
Type:
Small organic molecule
Emp. Form.:
C14H22N2O4
Mol. Mass.:
282.3355
SMILES:
OCC(NC[C@H]1N[C@H](CO)[C@H](O)[C@@H]1O)c1ccccc1
Structure:
Search PDB for entries with ligand similarity: