Target
Procathepsin L
Ligand
BDBM50169487
Substrate
n/a
Meas. Tech.
ChEMBL_306539 (CHEMBL827828)
IC50
15000±n/a nM
Citation
 Barrett, DGBoncek, VMCatalano, JGDeaton, DNHassell, AMJurgensen, CHLong, STMcFadyen, RBMiller, ABMiller, LRPayne, JARay, JASamano, VShewchuk, LMTavares, FXWells-Knecht, KJWillard, DHWright, LLZhou, HQ P2-P3 conformationally constrained ketoamide-based inhibitors of cathepsin K. Bioorg Med Chem Lett 15:3540-6 (2005) [PubMed]  Article 
Target
Name:
Procathepsin L
Synonyms:
CATL1_HUMAN | CTSL | CTSL CTSL1 | CTSL1 | Cathepsin L | Cathepsin L1 | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein
Type:
Enzyme
Mol. Mass.:
37557.19
Organism:
Homo sapiens (Human)
Description:
Purchased from Calbiochem (San Diego, CA).
Residue:
333
Sequence:
MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
  
Inhibitor
Name:
BDBM50169487
Synonyms:
CHEMBL426617 | [(S)-1-((S)-2-Oxo-piperidin-3-ylaminooxalyl)-pentyl]-carbamic acid 1-[5-(4-fluoro-phenyl)-[1,3,4]oxadiazol-2-ylmethyl]-2,2-dimethyl-propyl ester
Type:
Small organic molecule
Emp. Form.:
C27H36FN5O6
Mol. Mass.:
545.603
SMILES:
CCCC[C@H](NC(=O)OC(Cc1nnc(o1)-c1ccc(F)cc1)C(C)(C)C)C(=O)C(=O)N[C@H]1CCCNC1=O
Structure:
Search PDB for entries with ligand similarity: