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TargetCathepsin L1
LigandBDBM50169483
Substrate/Competitorn/a
Meas. Tech.ChEMBL_306539
IC50 33000±n/a nM
Citation Barrett, DGBoncek, VMCatalano, JGDeaton, DNHassell, AMJurgensen, CHLong, STMcFadyen, RBMiller, ABMiller, LRPayne, JARay, JASamano, VShewchuk, LMTavares, FXWells-Knecht, KJWillard, DHWright, LLZhou, HQ P2-P3 conformationally constrained ketoamide-based inhibitors of cathepsin K. Bioorg Med Chem Lett15:3540-6 (2005) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cathepsin L1
Name:Cathepsin (L and K)
Synonyms:Cathepsin (L and K) | Cathepsin L | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein
Type:Enzyme
Mol. Mass.:37557.19
Organism:Homo sapiens (Human)
Description:Purchased from Calbiochem (San Diego, CA).
Residue:333
Sequence:
MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIE
LHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDW
REKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNG
GLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVA
TVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKN
SWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50169483
NameBDBM50169483
Synonyms:(R)-1-(5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl)-3,3-dimethylbutan-2-yl(S)-1,2-dioxo-1-((R)-1-phenylethylamino)heptan-3-ylcarbamate | CHEMBL188438 | [(S)-1-(1-Phenyl-ethylaminooxalyl)-pentyl]-carbamic acid (R)-1-[5-(4-fluoro-phenyl)-[1,3,4]oxadiazol-2-ylmethyl]-2,2-dimethyl-propyl ester
TypeSmall organic molecule
Emp. Form.C30H37FN4O5
Mol. Mass.552.637
SMILESCCCC[C@H](NC(=O)O[C@H](Cc1nnc(o1)-c1ccc(F)cc1)C(C)(C)C)C(=O)C(=O)N[C@H](C)c1ccccc1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
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