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Target
Corticotropin-releasing factor receptor 1
Ligand
BDBM50171334
Substrate
n/a
Meas. Tech.
ChEMBL_303781 (CHEMBL830138)
Ki
17±n/a nM
Citation
 Guo, Z; Tellew, JE; Gross, RS; Dyck, B; Grey, J; Haddach, M; Kiankarimi, M; Lanier, M; Li, BF; Luo, Z; McCarthy, JR; Moorjani, M; Saunders, J; Sullivan, R; Zhang, X; Zamani-Kord, S; Grigoriadis, DE; Crowe, PD; Chen, TK; Williams, JP Design and synthesis of tricyclic imidazo[4,5-b]pyridin-2-ones as corticotropin-releasing factor-1 antagonists. J Med Chem 48:5104-7 (2005) [PubMed]  Article 
Target
Name:
Corticotropin-releasing factor receptor 1
Synonyms:
CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1
Type:
Enzyme
Mol. Mass.:
50744.31
Organism:
Homo sapiens (Human)
Description:
P34998
Residue:
444
Sequence:
MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
  
Inhibitor
Name:
BDBM50171334
Synonyms:
7-Methyl-5-(1-propyl-butyl)-1-(4-trifluoromethyl-phenyl)-4,5-dihydro-1H,3H-1,2a,5,8-tetraaza-acenaphthylen-2-one | CHEMBL189780
Type:
Small organic molecule
Emp. Form.:
C23H27F3N4O
Mol. Mass.:
432.4819
SMILES:
CCCC(CCC)N1CCn2c3c1cc(C)nc3n(-c1ccc(cc1)C(F)(F)F)c2=O
Structure:
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