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Target
Caspase-3
Ligand
BDBM50171417
Substrate
n/a
Meas. Tech.
ChEMBL_304239 (CHEMBL877120)
EC50
900±n/a nM
Citation
 Zhang, HZ; Kasibhatla, S; Kuemmerle, J; Kemnitzer, W; Ollis-Mason, K; Qiu, L; Crogan-Grundy, C; Tseng, B; Drewe, J; Cai, SX Discovery and structure-activity relationship of 3-aryl-5-aryl-1,2,4-oxadiazoles as a new series of apoptosis inducers and potential anticancer agents. J Med Chem 48:5215-23 (2005) [PubMed]  Article 
Target
Name:
Caspase-3
Synonyms:
Apopain | CASP-3 | CASP3 | CASP3_HUMAN | CPP-32 | CPP32 | Caspase 3 | Caspase-3 subunit p12 | Caspase-3 subunit p17 | Cysteine protease CPP32 | SCA-1 | SREBP cleavage activity 1 | Yama protein | caspase-3 preproprotein
Type:
Hydrolase; heterotetramer of two heterodimers
Mol. Mass.:
31607.55
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
277
Sequence:
MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDDDMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH
  
Inhibitor
Name:
BDBM50171417
Synonyms:
5-(3-Chloro-thiophen-2-yl)-3-(3-trifluoromethyl-phenyl)-[1,2,4]oxadiazole | CHEMBL365384
Type:
Small organic molecule
Emp. Form.:
C13H6ClF3N2OS
Mol. Mass.:
330.713
SMILES:
FC(F)(F)c1cccc(c1)-c1noc(n1)-c1sccc1Cl
Structure:
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