Reaction Details Report a problem with these data
Target
Enoyl-acyl-carrier protein reductase
Ligand
BDBM50174755
Substrate
n/a
Meas. Tech.
ChEMBL_326719 (CHEMBL858717)
IC50
250±n/a nM
Citation
Freundlich, JS; Anderson, JW; Sarantakis, D; Shieh, HM; Yu, M; Valderramos, JC; Lucumi, E; Kuo, M; Jacobs, WR; Fidock, DA; Schiehser, GA; Jacobus, DP; Sacchettini, JC Synthesis, biological activity, and X-ray crystal structural analysis of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 1: 4'-substituted triclosan derivatives. Bioorg Med Chem Lett 15:5247-52 (2005) [PubMed] Article
More Info.:
Target
Name:
Enoyl-acyl-carrier protein reductase
Synonyms:
n/a
Type:
PROTEIN
Mol. Mass.:
49770.86
Organism:
Plasmodium falciparum
Description:
ChEMBL_795989
Residue:
432
Sequence:
MNKISQRLLFLFLHFYTTVCFIQNNTQKTFHNVLQNEQIRGKEKAFYRKEKRENIFIGNKMKHVHNMNNTHNNNHYMEKEEQDASNINKIKEENKNEDICFIAGIGDTNGYGWGIAKELSKRNVKIIFGIWPPVYNIFMKNYKNGKFDNDMIIDKDKKMNILDMLPFDASFDTANDIDEETKNNKRYNMLQNYPIEDVANLIHQKYGKINMLVHSLANAKEVQKDLLNTSRKGYLDALSKSSYSLISLCKYFVNIMKPQSSIISLTYHASQKVVPGYGGGMSSAKAALESDTRVLAYHLGRNYNIRINTISAGPLKSRAATAINKLNNTYENNTNQNKNRNSHDVHNIMNNSGEKEEKKNSASQNYTFIDYAIEYSEKYAPLRQKLLSTDIGSVASFLLSRESRAITGQTIYVDNGLNIMFLPDDIYRNENE
Inhibitor
Name:
BDBM50174755
Synonyms:
CHEMBL198831 | N-(3-chloro-4-(4-chloro-2-hydroxyphenoxy)phenyl)morpholine-4-carboxamide | N-[3-CHLORO-4-(4-CHLORO-2-HYDROXYPHENOXY)PHENYL]MORPHOLINE-4-CARBOXAMIDE
Type:
Small organic molecule
Emp. Form.:
C17H16Cl2N2O4
Mol. Mass.:
383.226
SMILES:
Oc1cc(Cl)ccc1Oc1ccc(NC(=O)N2CCOCC2)cc1Cl