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Target
Enoyl-acyl-carrier protein reductase
Ligand
BDBM50174767
Substrate
n/a
Meas. Tech.
ChEMBL_326719 (CHEMBL858717)
IC50
190±n/a nM
Citation
 Freundlich, JS; Anderson, JW; Sarantakis, D; Shieh, HM; Yu, M; Valderramos, JC; Lucumi, E; Kuo, M; Jacobs, WR; Fidock, DA; Schiehser, GA; Jacobus, DP; Sacchettini, JC Synthesis, biological activity, and X-ray crystal structural analysis of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 1: 4'-substituted triclosan derivatives. Bioorg Med Chem Lett 15:5247-52 (2005) [PubMed]  Article 
Target
Name:
Enoyl-acyl-carrier protein reductase
Synonyms:
n/a
Type:
PROTEIN
Mol. Mass.:
49770.86
Organism:
Plasmodium falciparum
Description:
ChEMBL_795989
Residue:
432
Sequence:
MNKISQRLLFLFLHFYTTVCFIQNNTQKTFHNVLQNEQIRGKEKAFYRKEKRENIFIGNKMKHVHNMNNTHNNNHYMEKEEQDASNINKIKEENKNEDICFIAGIGDTNGYGWGIAKELSKRNVKIIFGIWPPVYNIFMKNYKNGKFDNDMIIDKDKKMNILDMLPFDASFDTANDIDEETKNNKRYNMLQNYPIEDVANLIHQKYGKINMLVHSLANAKEVQKDLLNTSRKGYLDALSKSSYSLISLCKYFVNIMKPQSSIISLTYHASQKVVPGYGGGMSSAKAALESDTRVLAYHLGRNYNIRINTISAGPLKSRAATAINKLNNTYENNTNQNKNRNSHDVHNIMNNSGEKEEKKNSASQNYTFIDYAIEYSEKYAPLRQKLLSTDIGSVASFLLSRESRAITGQTIYVDNGLNIMFLPDDIYRNENE
  
Inhibitor
Name:
BDBM50174767
Synonyms:
2-(3-chloro-4-(4-chloro-2-hydroxyphenoxy)phenyl)acetonitrile | CHEMBL200533
Type:
Small organic molecule
Emp. Form.:
C14H9Cl2NO2
Mol. Mass.:
294.133
SMILES:
Oc1cc(Cl)ccc1Oc1ccc(CC#N)cc1Cl
Structure:
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