Reaction Details Report a problem with these data
Target
Methionine aminopeptidase
Ligand
BDBM50175435
Substrate
n/a
Meas. Tech.
ChEMBL_326947 (CHEMBL853289)
IC50
>200000±n/a nM
Citation
 Huang, QQ; Huang, M; Nan, FJ; Ye, QZ Metalloform-selective inhibition: synthesis and structure-activity analysis of Mn(II)-form-selective inhibitors of Escherichia coli methionine aminopeptidase. Bioorg Med Chem Lett 15:5386-91 (2005) [PubMed]  Article 
Target
Name:
Methionine aminopeptidase
Synonyms:
EcMetAP | MAP1_ECOLI | Methionine Aminopeptidase (MAP) | Methionine aminopeptidase | Peptidase M | map
Type:
Enzyme
Mol. Mass.:
29326.96
Organism:
Escherichia coli (strain K12)
Description:
Full-length untagged EcMAP was expressed in E. coli.
Residue:
264
Sequence:
MAISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGRGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISHDE
  
Inhibitor
Name:
BDBM50175435
Synonyms:
5-(2-carboxyphenyl)furan-2-carboxylic acid | CHEMBL197760
Type:
Small organic molecule
Emp. Form.:
C12H8O5
Mol. Mass.:
232.1889
SMILES:
OC(=O)c1ccc(o1)-c1ccccc1C(O)=O
Structure:
Search PDB for entries with ligand similarity: