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Target
Procathepsin L
Ligand
BDBM19769
Substrate
n/a
Meas. Tech.
ChEMBL_321690 (CHEMBL872185)
Ki
2.2±n/a nM
Citation
 Marquis, RW; James, I; Zeng, J; Trout, RE; Thompson, S; Rahman, A; Yamashita, DS; Xie, R; Ru, Y; Gress, CJ; Blake, S; Lark, MA; Hwang, SM; Tomaszek, T; Offen, P; Head, MS; Cummings, MD; Veber, DF Azepanone-based inhibitors of human cathepsin L. J Med Chem 48:6870-8 (2005) [PubMed]  Article 
Target
Name:
Procathepsin L
Synonyms:
CATL1_HUMAN | CTSL | CTSL CTSL1 | CTSL1 | Cathepsin L | Cathepsin L1 | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein
Type:
Enzyme
Mol. Mass.:
37557.19
Organism:
Homo sapiens (Human)
Description:
Purchased from Calbiochem (San Diego, CA).
Residue:
333
Sequence:
MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
  
Inhibitor
Name:
BDBM19769
Synonyms:
(2S)-2-(1-benzofuran-2-ylformamido)-4-methyl-N-[(4S)-3-oxo-1-(pyridine-2-sulfonyl)azepan-4-yl]pentanamide | Azepan-3-one compound 1 | CHEMBL286364
Type:
Small organic molecule
Emp. Form.:
C26H30N4O6S
Mol. Mass.:
526.605
SMILES:
CC(C)C[C@H](NC(=O)c1cc2ccccc2o1)C(=O)N[C@H]1CCCN(CC1=O)S(=O)(=O)c1ccccn1 |r|
Structure:
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