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Target
Succinate-semialdehyde dehydrogenase, mitochondrial
Ligand
BDBM50177403
Substrate
n/a
Meas. Tech.
ChEMBL_332432 (CHEMBL867028)
IC50
>1000000±n/a nM
Citation
 Tao, YH; Yuan, Z; Tang, XQ; Xu, HB; Yang, XL Inhibition of GABA shunt enzymes' activity by 4-hydroxybenzaldehyde derivatives. Bioorg Med Chem Lett 16:592-5 (2005) [PubMed]  Article 
Target
Name:
Succinate-semialdehyde dehydrogenase, mitochondrial
Synonyms:
ALDH5A1 | Aldehyde dehydrogenase family 5 member A1 | NAD(+)-dependent succinic semialdehyde dehydrogenase | SSADH | SSDH_HUMAN | Succinate semialdehyde dehydrogenase | Succinate-semialdehyde dehydrogenase, mitochondrial
Type:
PROTEIN
Mol. Mass.:
57224.70
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1459249
Residue:
535
Sequence:
MATCIWLRSCGARRLGSTFPGCRLRPRAGGLVPASGPAPGPAQLRCYAGRLAGLSAALLRTDSFVGGRWLPAAATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYVCYGGL
  
Inhibitor
Name:
BDBM50177403
Synonyms:
(2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-(4-(hydroxymethyl)phenoxy)-tetrahydro-2H-pyran-3,4,5-triol | CHEMBL274739
Type:
Small organic molecule
Emp. Form.:
C13H18O7
Mol. Mass.:
286.2778
SMILES:
OC[C@H]1O[C@@H](Oc2ccc(CO)cc2)[C@H](O)[C@@H](O)[C@@H]1O
Structure:
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