Target
Cathepsin K
Ligand
BDBM50410612
Substrate
n/a
Meas. Tech.
ChEMBL_325792 (CHEMBL862698)
Ki
0.95±n/a nM
Citation
 Palmer, JTBryant, CWang, DXDavis, DESetti, ELRydzewski, RMVenkatraman, STian, ZQBurrill, LCMendonca, RVSpringman, EMcCarter, JChung, TCheung, HJanc, JWMcGrath, MSomoza, JREnriquez, PYu, ZWStrickley, RMLiu, LVenuti, MCPercival, MDFalgueyret, JPPrasit, POballa, RRiendeau, DYoung, RNWesolowski, GRodan, SBJohnson, CKimmel, DBRodan, G Design and synthesis of tri-ring P3 benzamide-containing aminonitriles as potent, selective, orally effective inhibitors of cathepsin K. J Med Chem 48:7520-34 (2005) [PubMed]  Article 
Target
Name:
Cathepsin K
Synonyms:
CATK_RABIT | CTSK
Type:
Enzyme
Mol. Mass.:
36879.51
Organism:
Oryctolagus cuniculus (rabbit)
Description:
n/a
Residue:
329
Sequence:
MWGLKVLLLPVVSFALHPEEILDTQWELWKKTYSKQYNSKVDEISRRLIWEKNLKHISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPPSRSHSNDTLYIPDWEGRTPDSIDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENYGCGGGYMTNAFQYVQRNRGIDSEDAYPYVGQDESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDENCSSDNVNHAVLAVGYGIQKGNKHWIIKNSWGESWGNKGYILMARNKNNACGIANLASFPKM
  
Inhibitor
Name:
BDBM50410612
Synonyms:
CHEMBL200166
Type:
Small organic molecule
Emp. Form.:
C26H33N5O2S
Mol. Mass.:
479.638
SMILES:
CN1CCC(C)(CC1)c1nc(cs1)-c1ccc(cc1)C(=O)NC1(CCCCC1)C(=O)NCC#N
Structure:
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