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Target
Sodium- and chloride-dependent glycine transporter 1
Ligand
BDBM50178424
Substrate
n/a
Meas. Tech.
ChEMBL_339708 (CHEMBL867170)
IC50
2.9±n/a nM
Citation
 Thomson, CG; Duncan, K; Fletcher, SR; Huscroft, IT; Pillai, G; Raubo, P; Smith, AJ; Stead, D Sarcosine based indandione hGlyT1 inhibitors. Bioorg Med Chem Lett 16:1388-91 (2006) [PubMed]  Article 
Target
Name:
Sodium- and chloride-dependent glycine transporter 1
Synonyms:
GlyT-1 | GlyT1 | Glycine Transporters (GlyT1c) | Glycine transporter 1 | SC6A9_HUMAN | SLC6A9 | Sodium- and chloride-dependent glycine transporter 1 | Sodium- and chloride-dependent glycine transporter 1 (GlyT1) | Sodium- and chloride-dependent glycine transporter 1 (GlyT1c) | Sodium-and chloride-dependent glycine transporter 1 (GlyT-1c) | Solute carrier family 6 member 9
Type:
Enzyme
Mol. Mass.:
78270.54
Organism:
Homo sapiens (Human)
Description:
P48067
Residue:
706
Sequence:
MSGGDTRAAIARPRMAAAHGPVAPSSPEQVTLLPVQRSFFLPPFSGATPSTSLAESVLKVWHGAYNSGLLPQLMAQHSLAMAQNGAVPSEATKRDQNLKRGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVWRISPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCNNPWNTHDCAGVLDASNLTNGSRPAALPSNLSHLLNHSLQRTSPSEEYWRLYVLKLSDDIGNFGEVRLPLLGCLGVSWLVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLEGAFDGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILGFMANHLGVDVSRVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVDEVGNEWILQKKTYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVISCIMCVAIMYIYGHRNYFQDIQMMLGFPPPLFFQICWRFVSPAIIFFILVFTVIQYQPITYNHYQYPGWAVAIGFLMALSSVLCIPLYAMFRLCRTDGDTLLQRLKNATKPSRDWGPALLEHRTGRYAPTIAPSPEDGFEVQPLHPDKAQIPIVGSNGSSRLQDSRI
  
Inhibitor
Name:
BDBM50178424
Synonyms:
(2S)-2-((2-(4,5-dichloro-6-methoxy-1,3-dioxo-2-phenyl-2,3-dihydro-1H-inden-2-yl)ethyl)(methyl)amino)-3-hydroxypropanoic acid | CHEMBL204397
Type:
Small organic molecule
Emp. Form.:
C22H21Cl2NO6
Mol. Mass.:
466.311
SMILES:
COc1cc2C(=O)C(CCN(C)[C@@H](CO)C(O)=O)(C(=O)c2c(Cl)c1Cl)c1ccccc1
Structure:
Search PDB for entries with ligand similarity: