Target
Thrombopoietin receptor
Ligand
BDBM50179472
Substrate
n/a
Meas. Tech.
ChEMBL_338314 (CHEMBL866538)
EC50
780±n/a nM
Citation
 Safonov, IGHeerding, DAKeenan, RMPrice, ATErickson-Miller, CLHopson, CBLevin, JLLord, KATapley, PM New benzimidazoles as thrombopoietin receptor agonists. Bioorg Med Chem Lett 16:1212-6 (2006) [PubMed]  Article 
Target
Name:
Thrombopoietin receptor
Synonyms:
C-mpl | CD_antigen=CD110 | MPL | Myeloproliferative leukemia protein | TPO-R | TPOR | TPOR_HUMAN
Type:
PROTEIN
Mol. Mass.:
71243.48
Organism:
Homo sapiens (Human)
Description:
ChEMBL_535587
Residue:
635
Sequence:
MPSWALFMVTSCLLLAPQNLAQVSSQDVSLLASDSEPLKCFSRTFEDLTCFWDEEEAAPSGTYQLLYAYPREKPRACPLSSQSMPHFGTRYVCQFPDQEEVRLFFPLHLWVKNVFLNQTRTQRVLFVDSVGLPAPPSIIKAMGGSQPGELQISWEEPAPEISDFLRYELRYGPRDPKNSTGPTVIQLIATETCCPALQRPHSASALDQSPCAQPTMPWQDGPKQTSPSREASALTAEGGSCLISGLQPGNSYWLQLRSEPDGISLGGSWGSWSLPVTVDLPGDAVALGLQCFTLDLKNVTCQWQQQDHASSQGFFYHSRARCCPRDRYPIWENCEEEEKTNPGLQTPQFSRCHFKSRNDSIIHILVEVTTAPGTVHSYLGSPFWIHQAVRLPTPNLHWREISSGHLELEWQHPSSWAAQETCYQLRYTGEGHQDWKVLEPPLGARGGTLELRPRSRYRLQLRARLNGPTYQGPWSSWSDPTRVETATETAWISLVTALHLVLGLSAVLGLLLLRWQFPAHYRRLRHALWPSLPDLHRVLGQYLRDTAALSPPKATVSDTCEEVEPSLLEILPKSSERTPLPLCSSQAQMDYRRLQPSCLGTMPLSVCPPMAESGSCCTTHIANHSYLPLSYWQQP
  
Inhibitor
Name:
BDBM50179472
Synonyms:
5-((2-(4-(3,4-dimethylphenyl)thiophen-2-yl)-1H-benzo[d]imidazol-5-yl)methylene)-2-thioxothiazolidin-4-one | CHEMBL204160
Type:
Small organic molecule
Emp. Form.:
C23H17N3OS3
Mol. Mass.:
447.596
SMILES:
Cc1ccc(cc1C)-c1csc(c1)-c1nc2ccc(C=C3SC(S)=NC3=O)cc2[nH]1 |w:19.20,c:25|
Structure:
Search PDB for entries with ligand similarity: