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TargetExcitatory amino acid transporter 2
LigandBDBM50180146
Substrate/Competitorn/a
Meas. Tech.ChEMBL_329871
Ki>400000±n/a nM
Citation Bunch, LNielsen, BJensen, AABräuner-Osborne, H Rational design and enantioselective synthesis of (1R,4S,5R,6S)-3-azabicyclo[3.3.0]octane-4,6-dicarboxylic acid - a novel inhibitor at human glutamate transporter subtypes 1, 2, and 3. J Med Chem49:172-8 (2006) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Excitatory amino acid transporter 2
Name:Excitatory amino acid transporter 2
Synonyms:EAAT2 | GLT1 | Glutamate/aspartate transporter II | SLC1A2 | Sodium-dependent glutamate/aspartate transporter 2 | Solute carrier family 1 member 2
Type:Enzyme Catalytic Domain
Mol. Mass.:62103.57
Organism:Homo sapiens (Human)
Description:Excitatory Amino Acid EAAT2 0 0::P43004
Residue:574
Sequence:
MASTEGANNMPKQVEVRMHDSHLGSEEPKHRHLGLRLCDKLGKNLLLTLTVFGVILGAVC
GGLLRLASPIHPDVVMLIAFPGDILMRMLKMLILPLIISSLITGLSGLDAKASGRLGTRA
MVYYMSTTIIAAVLGVILVLAIHPGNPKLKKQLGPGKKNDEVSSLDAFLDLIRNLFPENL
VQACFQQIQTVTKKVLVAPPPDEEANATSAVVSLLNETVTEVPEETKMVIKKGLEFKDGM
NVLGLIGFFIAFGIAMGKMGDQAKLMVDFFNILNEIVMKLVIMIMWYSPLGIACLICGKI
IAIKDLEVVARQLGMYMVTVIIGLIIHGGIFLPLIYFVVTRKNPFSFFAGIFQAWITALG
TASSAGTLPVTFRCLEENLGIDKRVTRFVLPVGATINMDGTALYEAVAAIFIAQMNGVVL
DGGQIVTVSLTATLASVGAASIPSAGLVTMLLILTAVGLPTEDISLLVAVDWLLDRMRTS
VNVVGDSFGAGIVYHLSKSELDTIDSQHRVHEDIEMTKTQSIYDDMKNHRESNSNQCVYA
AHNSVIVDECKVTLAANGKSADCSVEEEPWKREK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50180146
NameBDBM50180146
Synonyms:(3S,5S)-2-aza-bicyclo[2.2.1]heptane-3,5-dicarboxylic acid | CHEMBL199331
TypeSmall organic molecule
Emp. Form.C8H11NO4
Mol. Mass.185.1772
SMILESOC(=O)[C@H]1CC2CC1[C@H](N2)C(O)=O |THB:10:8:6:4.3,1:3:8.9:6|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a