Reaction Details Report a problem with these data
Target
Matrix metalloproteinase-26
Ligand
BDBM50062351
Substrate
n/a
Meas. Tech.
ChEMBL_330174 (CHEMBL865846)
IC50
17±n/a nM
Citation
 Ma, D; Jiang, Y; Chen, F; Gong, LK; Ding, K; Xu, Y; Wang, R; Ge, A; Ren, J; Li, J; Li, J; Ye, Q Selective inhibition of matrix metalloproteinase isozymes and in vivo protection against emphysema by substituted gamma-keto carboxylic acids. J Med Chem 49:456-8 (2006) [PubMed]  Article 
Target
Name:
Matrix metalloproteinase-26
Synonyms:
Endometase | MMP-26 | MMP26 | MMP26_HUMAN | Matrilysin-2 | Matrix metalloproteinase 26 | Matrix metalloproteinase-26
Type:
PROTEIN
Mol. Mass.:
29707.55
Organism:
Homo sapiens (Human)
Description:
ChEMBL_806653
Residue:
261
Sequence:
MQLVILRVTIFLPWCFAVPVPPAADHKGWDFVEGYFHQFFLTKKESPLLTQETQTQLLQQFHRNGTDLLDMQMHALLHQPHCGVPDGSDTSISPGRCKWNKHTLTYRIINYPHDMKPSAVKDSIYNAVSIWSNVTPLIFQQVQNGDADIKVSFWQWAHEDGWPFDGPGGILGHAFLPNSGNPGVVHFDKNEHWSASDTGYNLFLVATHEIGHSLGLQHSGNQSSIMYPTYWYHDPRTFQLSADDIQRIQHLYGEKCSSDIP
  
Inhibitor
Name:
BDBM50062351
Synonyms:
(R)-N*4*-Hydroxy-N*1*-[(S)-2-(1H-indol-3-yl)-1-methylcarbamoyl-ethyl]-2-isobutyl-succinamide | (R)-N*4*-Hydroxy-N*1*-[2-(1H-indol-3-yl)-1-methylcarbamoyl-ethyl]-2-isobutyl-succinamide | (R)-N1-((S)-3-(1H-indol-3-yl)-1-(methylamino)-1-oxopropan-2-yl)-N4-hydroxy-2-isobutylsuccinamide | 3-(N-HYDROXYCARBOXAMIDO)-2-ISOBUTYLPROPANOYL-TRP-METHYLAMIDE | CHEMBL19611 | Ilomastat | US9487462, ilomastat
Type:
Small organic molecule
Emp. Form.:
C20H28N4O4
Mol. Mass.:
388.4607
SMILES:
CNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(C)C)CC(=O)NO |r|
Structure:
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