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Target
Phospholipase B
Ligand
BDBM50060533
Substrate
n/a
Meas. Tech.
ChEMBL_330127 (CHEMBL858987)
IC50
>250000±n/a nM
Citation
 Ng, CK; Obando, D; Widmer, F; Wright, LC; Sorrell, TC; Jolliffe, KA Correlation of antifungal activity with fungal phospholipase inhibition using a series of bisquaternary ammonium salts. J Med Chem 49:811-6 (2006) [PubMed]  Article 
Target
Name:
Phospholipase B
Synonyms:
PLB | PLB1 | PLB1_CRYNB
Type:
PROTEIN
Mol. Mass.:
68557.23
Organism:
Cryptococcus neoformans
Description:
ChEMBL_330127
Residue:
637
Sequence:
MSIITTAFALSLLATTAFAVPPETPRIELQAERGLGDQSYAPWQVDCPSNVTWIRNATTGLGTGERAYIEAREKLVQPAIEQMMAARGLETPPRTPVIGVALAGGGYRAMLTGLGGIMGMMNESTEASQSETGGWLDGVSYWSGLSGGSWATGSFMSNGGQLPTTLLENLWNIDSNLVFPDDGKLSFYTNLYTETNAKSDLGFPVQITDIWGLAIGSHVLPEPYQLSNTPNLTFSSLPSVVAALGNASLPMPIIVAADRKRREAGELVIAENATVWEFTPYEFGSWAFGSQYKSPGAFTPIEYLGTSVDDGSPNGTCWKGFDQLSFVMGTSATLFNGAFLELNGTDSGLLTNLITAFLADLGEDQADISRIPNSFSNYNSGENPIYNLTYITLVDAGETNQNIPLEPLLVPTRDVDAIVAFDSSYDSDYIWPNGTALRTTYERAKILAEHENTRVLMPEVPSMNGFVNGGYNSRPTFFGCNDTTTPVIIYIPSYPWSFAANTSTYQLSYENNEANEMLLNGMRSLTLNHSVPTWPTCFACALTDRSFMYTSENRSTTCQECFDTWCWAGDDNTTEPANYEPVINSVPPWLIANNLSIGMADAPGSNESTAGTASSGAAKMGVGMGMVALTAGLGLML
  
Inhibitor
Name:
BDBM50060533
Synonyms:
1,12-Bis(trimethyl ammonium)dodecane dibromide | 1,12-bis-(trimethyl ammonium) dodecane dibromide | CHEMBL119701 | Dodecamethonium | N,N,N,N',N',N'-Hexamethyl-1,12-dodecane diaminium dibromide | N,N,N,N',N',N'-Hexamethyldodecane-1,12-diammoniumdibromide | N1,N1,N1,N12,N12,N12-hexamethyldodecane-1,12-diaminium bromide | dodecane-1,12-bis(trimethylammonium bromide)
Type:
Small organic molecule
Emp. Form.:
C18H42N2
Mol. Mass.:
286.5384
SMILES:
C[N+](C)(C)CCCCCCCCCCCC[N+](C)(C)C
Structure:
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