Target
Sodium-dependent noradrenaline transporter
Ligand
BDBM50183146
Substrate
n/a
Meas. Tech.
ChEMBL_355136 (CHEMBL853189)
Ki
8.3±n/a nM
Citation
 Boot, JRBoulet, SLClark, BPCases-Thomas, MJDelhaye, LDiker, KFairhurst, JFindlay, JGallagher, PTGilmore, JHarris, JRMasters, JJMitchell, SNNaik, MSimmonds, RGSmith, SMRichards, SJTimms, GHWhatton, MAWolfe, CNWood, VA N-Alkyl-N-arylmethylpiperidin-4-amines: novel dual inhibitors of serotonin and norepinephrine reuptake. Bioorg Med Chem Lett 16:2714-8 (2006) [PubMed]  Article 
Target
Name:
Sodium-dependent noradrenaline transporter
Synonyms:
Monoamine transporter | NAT1 | NET | NET1 | Noradrenaline Transporter (NET) | Norepinephrine Transporter (NET) | Norepinephrine transporter protein (NET) | SC6A2_HUMAN | SLC6A2 | SLC6A5 | Sodium-dependent noradrenaline transporter (NET) | Solute carrier family 6 member 2
Type:
Multi-pass membrane protein
Mol. Mass.:
69337.72
Organism:
Homo sapiens (Human)
Description:
P23975
Residue:
617
Sequence:
MLLARMNPQVQPENNGADTGPEQPLRARKTAELLVVKERNGVQCLLAPRDGDAQPRETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYNREGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLPWTDCGHTWNSPNCTDPKLLNGSVLGNHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLCLMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFYRLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSSINCITSFVSGFAIFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVVFFVMLLALGLDSSMGGMEAVITGLADDFQVLKRHRKLFTFGVTFSTFLLALFCITKGGIYVLTLLDTFAAGTSILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFVSPAFLLFVVVVSIINFKPLTYDDYIFPPWANWVGWGIALSSMVLVPIYVIYKFLSTQGSLWERLAYGITPENEHHLVAQRDIRQFQLQHWLAI
  
Inhibitor
Name:
BDBM50183146
Synonyms:
CHEMBL426316 | N-(4-fluoro-2-(trifluoromethyl)benzyl)-N-butylpiperidin-4-amine fumaric acid salt
Type:
Small organic molecule
Emp. Form.:
C17H24F4N2
Mol. Mass.:
332.3795
SMILES:
CCCCN(Cc1ccc(F)cc1C(F)(F)F)C1CCNCC1
Structure:
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