Reaction Details Report a problem with these data
Target
Beta-glucosidase
Ligand
BDBM50186735
Substrate
n/a
Meas. Tech.
ChEMBL_353422 (CHEMBL861356)
pH
5±n/a
Ki
92000±n/a nM
Comments
extracted
Citation
 Wang, RW; Qiu, XL; Bols, M; Ortega-Caballero, F; Qing, FL Synthesis and biological evaluation of glycosidase inhibitors: gem-difluoromethylenated nojirimycin analogues. J Med Chem 49:2989-97 (2006) [PubMed]  Article 
Target
Name:
Beta-glucosidase
Synonyms:
n/a
Type:
PROTEIN
Mol. Mass.:
60428.49
Organism:
Prunus avium
Description:
ChEMBL_37428
Residue:
531
Sequence:
LLLLGFALANTNAARTDPPVVCATLNRTNFDTLFPGFTFGTATASYQLEGAANIDGRGPSIWDAFTHNHPEKITDGSNGDVAIDQYHRYKEDVAIMKDMGLDAYRFSISWSRLLPNGTLSGGINKKGIEYYNNLTNELIRNGIEPLVTLFHWDVPQALEEEYGGVLSPRIVYDFKAYAELCYKEFGDRVKHWTTLNEPYTISNHGYTIGIHAPGRCSSWYDPTCLGGDSGTEPYLVTHNLLLAHAAAVKLYREKYQASQEGVIGITVVSHWFEPASESQKDINASVRALDFMYGWFMDPLTRGDYPQSMRSLVKERLPNFTEEQSKSLIGSYDYIGVNYYSARYASAYPEDYSIPTPPSYLTDAYVNVTTELNGVPIGPQAASDWLYVYPKGLYDLVLYTKNKYNDPIMYITENGMDEFNNPKISLEQALNDSNRIDYCYRHLCYLQEAIIEGANVQGYFAWSLLDNFEWSEGYTVRFGINYVDYDNGLKRHSKLSTHWFKNFLKRSSISKEKIRRCGNNNARARKFVYRI
  
Inhibitor
Name:
BDBM50186735
Synonyms:
CHEMBL208021 | D-1,4-dideoxy-4,4-difluoromannonojirimycin
Type:
Small organic molecule
Emp. Form.:
C6H11F2NO3
Mol. Mass.:
183.1532
SMILES:
OC[C@H]1NC[C@@H](O)[C@@H](O)C1(F)F
Structure:
Search PDB for entries with ligand similarity: