Reaction Details Report a problem with these data
Target
Melanocortin receptor 4
Ligand
BDBM50186888
Substrate
n/a
Meas. Tech.
ChEMBL_376465 (CHEMBL863666)
Ki
310±n/a nM
Citation
 Tran, JA; Pontillo, J; Fleck, BA; Marinkovic, D; Arellano, M; Tucci, FC; Lanier, M; Saunders, J; Jiang, W; Chen, CW; Foster, AC; Chen, C Design, synthesis, and SAR studies on a series of 2-pyridinylpiperazines as potent antagonists of the melanocortin-4 receptor. Bioorg Med Chem Lett 16:3693-6 (2006) [PubMed]  Article 
Target
Name:
Melanocortin receptor 4
Synonyms:
MC4-R | MC4R | MC4R_HUMAN | Melanocortin MC4 | Melanocortin receptor 4 (MC-4) | Melanocortin receptor 4 (MC4-R) | Melanocortin receptor 4 (MC4R)
Type:
Enzyme
Mol. Mass.:
36949.50
Organism:
Homo sapiens (Human)
Description:
P32245
Residue:
332
Sequence:
MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVSGILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIICCYPLGGLCDLSSRY
  
Inhibitor
Name:
BDBM50186888
Synonyms:
(R)-3-amino-N-(3-(2,4-dichlorophenyl)-1-oxo-1-(4-(3-((2-(thiophen-2-yl)acetamido)methyl)pyridin-2-yl)piperazin-1-yl)propan-2-yl)propanamide | CHEMBL448475
Type:
Small organic molecule
Emp. Form.:
C28H32Cl2N6O3S
Mol. Mass.:
603.563
SMILES:
NCCC(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(CC1)c1ncccc1CNC(=O)Cc1cccs1
Structure:
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