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Target
N-formyl peptide receptor 2
Ligand
BDBM50186953
Substrate
n/a
Meas. Tech.
ChEMBL_376306 (CHEMBL867962)
EC50
44±n/a nM
Citation
 Bürli, RW; Xu, H; Zou, X; Muller, K; Golden, J; Frohn, M; Adlam, M; Plant, MH; Wong, M; McElvain, M; Regal, K; Viswanadhan, VN; Tagari, P; Hungate, R Potent hFPRL1 (ALXR) agonists as potential anti-inflammatory agents. Bioorg Med Chem Lett 16:3713-8 (2006) [PubMed]  Article 
Target
Name:
N-formyl peptide receptor 2
Synonyms:
ALXR, FPRL1, FPR2 | FMLP-related receptor I FMLP-R-I | FPR2 | FPR2_HUMAN | FPRH1 | FPRL1 | Formyl Peptide Receptor-Like 1 | HM63 | LXA4 receptor | LXA4R | Lipoxin A4 receptor | Lipoxin A4 receptor (LXA4) | RFP | hFPRL
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
38968.35
Organism:
Homo sapiens (Human)
Description:
P25090
Residue:
351
Sequence:
METNFSTPLNEYEEVSYESAGYTVLRILPLVVLGVTFVLGVLGNGLVIWVAGFRMTRTVTTICYLNLALADFSFTATLPFLIVSMAMGEKWPFGWFLCKLIHIVVDINLFGSVFLIGFIALDRCICVLHPVWAQNHRTVSLAMKVIVGPWILALVLTLPVFLFLTTVTIPNGDTYCTFNFASWGGTPEERLKVAITMLTARGIIRFVIGFSLPMSIVAICYGLIAAKIHKKGMIKSSRPLRVLTAVVASFFICWFPFQLVALLGTVWLKEMLFYGKYKIIDILVNPTSSLAFFNSCLNPMLYVFVGQDFRERLIHSLPTSLERALSEDSAPTNDTAANSASPPAETELQAM
  
Inhibitor
Name:
BDBM50186953
Synonyms:
1-(3-isopropyl-2-methyl-5-oxo-1-(quinolin-3-yl)-2,5-dihydro-1H-pyrazol-4-yl)-3-(4-(trifluoromethyl)phenyl)urea | CHEMBL380389
Type:
Small organic molecule
Emp. Form.:
C24H22F3N5O2
Mol. Mass.:
469.459
SMILES:
CC(C)c1c(NC(=O)Nc2ccc(cc2)C(F)(F)F)c(=O)n(-c2cnc3ccccc3c2)n1C
Structure:
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