Reaction Details Report a problem with these data
Target
Adenosine receptor A2b
Ligand
BDBM50188541
Substrate
n/a
Meas. Tech.
ChEMBL_364154 (CHEMBL870844)
Ki
2100±n/a nM
Citation
 Kalla, RV; Elzein, E; Perry, T; Li, X; Palle, V; Varkhedkar, V; Gimbel, A; Maa, T; Zeng, D; Zablocki, J Novel 1,3-disubstituted 8-(1-benzyl-1H-pyrazol-4-yl) xanthines: high affinity and selective A2B adenosine receptor antagonists. J Med Chem 49:3682-92 (2006) [PubMed]  Article 
Target
Name:
Adenosine receptor A2b
Synonyms:
AA2BR_HUMAN | ADENOSINE A2B | ADORA2B | Adenosine receptor A2B (A2B) | Adenosine receptors A2b | Adenosine receptors; A2a & A2b
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36341.22
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
332
Sequence:
MLLETQDALYVALELVIAALSVAGNVLVCAAVGTANTLQTPTNYFLVSLAAADVAVGLFAIPFAITISLGFCTDFYGCLFLACFVLVLTQSSIFSLLAVAVDRYLAICVPLRYKSLVTGTRARGVIAVLWVLAFGIGLTPFLGWNSKDSATNNCTEPWDGTTNESCCLVKCLFENVVPMSYMVYFNFFGCVLPPLLIMLVIYIKIFLVACRQLQRTELMDHSRTTLQREIHAAKSLAMIVGIFALCWLPVHAVNCVTLFQPAQGKNKPKWAMNMAILLSHANSVVNPIVYAYRNRDFRYTFHKIISRYLLCQADVKSGNGQAGVQPALGVGL
  
Inhibitor
Name:
BDBM50188541
Synonyms:
8-(1-ethyl-3-methyl-1H-pyrazol-5-yl)-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione | CHEMBL379838
Type:
Small organic molecule
Emp. Form.:
C17H24N6O2
Mol. Mass.:
344.4115
SMILES:
CCCn1c2nc([nH]c2c(=O)n(CCC)c1=O)-c1cc(C)nn1CC
Structure:
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