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Target
Cytochrome P450 2C9
Ligand
BDBM50189987
Substrate
n/a
Meas. Tech.
ChEMBL_391265 (CHEMBL870461)
IC50
>18000±n/a nM
Citation
 Westaway, SM; Chung, YK; Davis, JB; Holland, V; Jerman, JC; Medhurst, SJ; Rami, HK; Stemp, G; Stevens, AJ; Thompson, M; Winborn, KY; Wright, J N-Tetrahydroquinolinyl, N-quinolinyl and N-isoquinolinyl biaryl carboxamides as antagonists of TRPV1. Bioorg Med Chem Lett 16:4533-6 (2006) [PubMed]  Article 
Target
Name:
Cytochrome P450 2C9
Synonyms:
(R)-limonene 6-monooxygenase | (S)-limonene 6-monooxygenase | CP2C9_HUMAN | CYP2C10 | CYP2C9 | CYPIIC9 | Cytochrome P450 2C9 (CYP2C9 ) | Cytochrome P450 2C9 (CYP2C9) | P-450MP | P450 MP-4/MP-8 | P450 PB-1 | S-mephenytoin 4-hydroxylase
Type:
Enzyme
Mol. Mass.:
55636.33
Organism:
Homo sapiens (Human)
Description:
P11712
Residue:
490
Sequence:
MDSLVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVPPFYQLCFIPV
  
Inhibitor
Name:
BDBM50189987
Synonyms:
6-phenyl-N-(quinolin-7-yl)nicotinamide | CHEMBL213390 | N-quinolin-7-yl-6-phenylnicotinamide
Type:
Small organic molecule
Emp. Form.:
C21H15N3O
Mol. Mass.:
325.3633
SMILES:
O=C(Nc1ccc2cccnc2c1)c1ccc(nc1)-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: