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Target
D(2) dopamine receptor
Ligand
BDBM50190067
Substrate
n/a
Meas. Tech.
ChEMBL_393314 (CHEMBL911524)
Ki
65±n/a nM
Citation
 Su, J; Tang, H; McKittrick, BA; Burnett, DA; Zhang, H; Smith-Torhan, A; Fawzi, A; Lachowicz, J Modification of the clozapine structure by parallel synthesis. Bioorg Med Chem Lett 16:4548-53 (2006) [PubMed]  Article 
Target
Name:
D(2) dopamine receptor
Synonyms:
D(2) dopamine receptor | DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2 | DRD2_HUMAN | Dopamine D2 receptor | Dopamine D2 receptor (D2) | Dopamine D2 receptor (D2R) | Dopamine D2A | Dopamine2-like | d2
Type:
Cell-surface receptors
Mol. Mass.:
50647.10
Organism:
Homo sapiens (Human)
Description:
P14416
Residue:
443
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
  
Inhibitor
Name:
BDBM50190067
Synonyms:
8-chloro-11-[4-(2,4-dimethyl-benzyl)-piperazin-1-yl]-5H-dibenzo[b,e][1,4]diazepine | CHEMBL378301
Type:
Small organic molecule
Emp. Form.:
C26H27ClN4
Mol. Mass.:
430.972
SMILES:
Cc1ccc(CN2CCN(CC2)C2=Nc3cc(Cl)ccc3Nc3ccccc23)c(C)c1 |t:13|
Structure:
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