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TargetAmiloride-sensitive sodium channel alpha-subunit
LigandBDBM50190457
Substrate/Competitorn/a
Meas. Tech.ChEMBL_375179
IC50 42±n/a nM
Citation Hirsh, AJMolino, BFZhang, JAstakhova, NGeiss, WBSargent, BJSwenson, BDUsyatinsky, AWyle, MJBoucher, RCSmith, RTZamurs, AJohnson, MR Design, synthesis, and structure-activity relationships of novel 2-substituted pyrazinoylguanidine epithelial sodium channel blockers: drugs for cystic fibrosis and chronic bronchitis. J Med Chem49:4098-115 (2006) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Amiloride-sensitive sodium channel alpha-subunit
Name:Amiloride-sensitive sodium channel alpha-subunit
Synonyms:Alpha-ENaC | Alpha-NaCH | Amiloride-sensitive sodium channel subunit alpha | Epithelial Na(+) channel subunit alpha | Nonvoltage-gated sodium channel 1 subunit alpha | SCNEA
Type:PROTEIN
Mol. Mass.:75711.44
Organism:Homo sapiens (Human)
Description:ChEMBL_375179
Residue:669
Sequence:
MEGNKLEEQDSSPPQSTPGLMKGNKREEQGLGPEPAAPQQPTAEEEALIEFHRSYRELFE
FFCNNTTIHGAIRLVCSQHNRMKTAFWAVLWLCTFGMMYWQFGLLFGEYFSYPVSLNINL
NSDKLVFPAVTICTLNPYRYPEIKEELEELDRITEQTLFDLYKYSSFTTLVAGSRSRRDL
RGTLPHPLQRLRVPPPPHGARRARSVASSLRDNNPQVDWKDWKIGFQLCNQNKSDCFYQT
YSSGVDAVREWYRFHYINILSRLPETLPSLEEDTLGNFIFACRFNQVSCNQANYSHFHHP
MYGNCYTFNDKNNSNLWMSSMPGINNGLSLMLRAEQNDFIPLLSTVTGARVMVHGQDEPA
FMDDGGFNLRPGVETSISMRKETLDRLGGDYGDCTKNGSDVPVENLYPSKYTQQVCIHSC
FQESMIKECGCAYIFYPRPQNVEYCDYRKHSSWGYCYYKLQVDFSSDHLGCFTKCRKPCS
VTSYQLSAGYSRWPSVTSQEWVFQMLSRQNNYTVNNKRNGVAKVNIFFKELNYKTNSESP
SVTMVTLLSNLGSQWSLWFGSSVLSVVEMAELVFDLLVIMFLMLLRRFRSRYWSPGRGGR
GAQEVASTLASSPPSHFCPHPMSLSLSQPGPAPSPALTAPPPAYATLGPRPSPGGSAGAS
SSTCPLGGP
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50190457
NameBDBM50190457
Synonyms:CHEMBL211072 | N-(3,5-diamino-6-chloropyrazine-2-carbonyl)-N'-[4-(3,4-dihydroxyphenyl)butyl]-guanidine
TypeSmall organic molecule
Emp. Form.C16H20ClN7O3
Mol. Mass.393.828
SMILESNC(NC(=O)c1nc(Cl)c(N)nc1N)=NCCCCc1ccc(O)c(O)c1 |w:14.15|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a