Reaction Details Report a problem with these data
Target
Amiloride-sensitive sodium channel subunit alpha
Ligand
BDBM115076
Substrate
n/a
Meas. Tech.
ChEMBL_375179 (CHEMBL868533)
IC50
401±n/a nM
Citation
 Hirsh, AJ; Molino, BF; Zhang, J; Astakhova, N; Geiss, WB; Sargent, BJ; Swenson, BD; Usyatinsky, A; Wyle, MJ; Boucher, RC; Smith, RT; Zamurs, A; Johnson, MR Design, synthesis, and structure-activity relationships of novel 2-substituted pyrazinoylguanidine epithelial sodium channel blockers: drugs for cystic fibrosis and chronic bronchitis. J Med Chem 49:4098-115 (2006) [PubMed]  Article 
Target
Name:
Amiloride-sensitive sodium channel subunit alpha
Synonyms:
Alpha-ENaC | Alpha-NaCH | Amiloride-sensitive sodium channel alpha-subunit | Amiloride-sensitive sodium channel subunit alpha | Epithelial Na(+) channel subunit alpha | Nonvoltage-gated sodium channel 1 subunit alpha | SCNEA | SCNN1 | SCNN1A | SCNNA_HUMAN
Type:
PROTEIN
Mol. Mass.:
75711.44
Organism:
Homo sapiens (Human)
Description:
ChEMBL_375179
Residue:
669
Sequence:
MEGNKLEEQDSSPPQSTPGLMKGNKREEQGLGPEPAAPQQPTAEEEALIEFHRSYRELFEFFCNNTTIHGAIRLVCSQHNRMKTAFWAVLWLCTFGMMYWQFGLLFGEYFSYPVSLNINLNSDKLVFPAVTICTLNPYRYPEIKEELEELDRITEQTLFDLYKYSSFTTLVAGSRSRRDLRGTLPHPLQRLRVPPPPHGARRARSVASSLRDNNPQVDWKDWKIGFQLCNQNKSDCFYQTYSSGVDAVREWYRFHYINILSRLPETLPSLEEDTLGNFIFACRFNQVSCNQANYSHFHHPMYGNCYTFNDKNNSNLWMSSMPGINNGLSLMLRAEQNDFIPLLSTVTGARVMVHGQDEPAFMDDGGFNLRPGVETSISMRKETLDRLGGDYGDCTKNGSDVPVENLYPSKYTQQVCIHSCFQESMIKECGCAYIFYPRPQNVEYCDYRKHSSWGYCYYKLQVDFSSDHLGCFTKCRKPCSVTSYQLSAGYSRWPSVTSQEWVFQMLSRQNNYTVNNKRNGVAKVNIFFKELNYKTNSESPSVTMVTLLSNLGSQWSLWFGSSVLSVVEMAELVFDLLVIMFLMLLRRFRSRYWSPGRGGRGAQEVASTLASSPPSHFCPHPMSLSLSQPGPAPSPALTAPPPAYATLGPRPSPGGSAGASSSTCPLGGP
  
Inhibitor
Name:
BDBM115076
Synonyms:
3,5-bis(azanyl)-N-[azanyl(phenylazanyl)methylidene]-6-chloranyl-pyrazine-2-carboxamide;methanesulfonic acid | 3,5-diamino-N-[amino(anilino)methylene]-6-chloro-pyrazinamide;mesylic acid | 3,5-diamino-N-[amino(anilino)methylidene]-6-chloro-2-pyrazinecarboxamide;methanesulfonic acid | 3,5-diamino-N-[amino(anilino)methylidene]-6-chloropyrazine-2-carboxamide;methanesulfonic acid | CHEMBL211502 | MLS002172443 | Phenamil methanesulfonate salt | SMR000326941 | cid_9604979
Type:
Small organic molecule
Emp. Form.:
C12H12ClN7O
Mol. Mass.:
305.723
SMILES:
NC(NC(=O)c1nc(Cl)c(N)nc1N)=Nc1ccccc1 |w:14.15|
Structure:
Search PDB for entries with ligand similarity: