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Target
Prostacyclin receptor
Ligand
BDBM50191136
Substrate
n/a
Meas. Tech.
ChEMBL_400373 (CHEMBL912671)
IC50
930±n/a nM
Citation
 Tanaka, A; Hattori, K; Taniguchi, K; Okitsu, O; Tabuchi, S; Nishio, M; Nagakura, Y; Maeda, N; Murai, H; Seki, J Replacing the cyclohexene-linker of FR181157 leading to novel IP receptor agonists: orally active prostacyclin mimetics. Part 6. Bioorg Med Chem Lett 16:4861-4 (2006) [PubMed]  Article 
Target
Name:
Prostacyclin receptor
Synonyms:
PGI receptor | PI2R_HUMAN | PRIPR | PTGIR | Prostacyclin (IP) Receptor | Prostacyclin receptor | Prostaglandin I | Prostaglandin I2 | Prostaglandin I2 receptor | Prostanoid IP receptor
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40968.22
Organism:
Homo sapiens (Human)
Description:
The membranes prepared from human platelet were used in binding assay.
Residue:
386
Sequence:
MADSCRNLTYVRGSVGPATSTLMFVAGVVGNGLALGILSARRPARPSAFAVLVTGLAATDLLGTSFLSPAVFVAYARNSSLLGLARGGPALCDAFAFAMTFFGLASMLILFAMAVERCLALSHPYLYAQLDGPRCARLALPAIYAFCVLFCALPLLGLGQHQQYCPGSWCFLRMRWAQPGGAAFSLAYAGLVALLVAAIFLCNGSVTLSLCRMYRQQKRHQGSLGPRPRTGEDEVDHLILLALMTVVMAVCSLPLTIRCFTQAVAPDSSSEMGDLLAFRFYAFNPILDPWVFILFRKAVFQRLKLWVCCLCLGPAHGDSQTPLSQLASGRRDPRAPSAPVGKEGSCVPLSAWGEGQVEPLPPTQQSSGSAVGTSSKAEASVACSLC
  
Inhibitor
Name:
BDBM50191136
Synonyms:
CHEMBL386580 | sodium 2-(3-(2-(4,5-diphenyloxazol-2-yl)benzyl)phenoxy)acetate
Type:
Small organic molecule
Emp. Form.:
C30H22NO4
Mol. Mass.:
460.5005
SMILES:
[O-]C(=O)COc1cccc(Cc2ccccc2-c2nc(c(o2)-c2ccccc2)-c2ccccc2)c1
Structure:
Search PDB for entries with ligand similarity: