Reaction Details Report a problem with these data
Target
Melanocortin receptor 3
Ligand
BDBM50191558
Substrate
n/a
Meas. Tech.
ChEMBL_376975 (CHEMBL871436)
EC50
2051±n/a nM
Citation
Tian, X; Field, TB; Switzer, AG; Mazur, AW; Ebetino, FH; Wos, JA; Berberich, SM; Jayasinghe, LR; Obringer, CM; Dowty, ME; Pinney, BB; Farmer, JA; Crossdoersen, D; Sheldon, RJ Design, synthesis, and evaluation of proline and pyrrolidine based melanocortin receptor agonists. A conformationally restricted dipeptide mimic approach. J Med Chem 49:4745-61 (2006) [PubMed] Article
More Info.:
Target
Name:
Melanocortin receptor 3
Synonyms:
MC3-R | MC3R | MC3R_HUMAN | Melanocortin MC3 | Melanocortin receptor (M3 and M4)
Type:
Enzyme
Mol. Mass.:
36044.86
Organism:
Homo sapiens (Human)
Description:
P41968
Residue:
323
Sequence:
MNASCCLPSVQPTLPNGSEHLQAPFFSNQSSSAFCEQVFIKPEVFLSLGIVSLLENILVILAVVRNGNLHSPMYFFLCSLAVADMLVSVSNALETIMIAIVHSDYLTFEDQFIQHMDNIFDSMICISLVASICNLLAIAVDRYVTIFYALRYHSIMTVRKALTLIVAIWVCCGVCGVVFIVYSESKMVIVCLITMFFAMMLLMGTLYVHMFLFARLHVKRIAALPPADGVAPQQHSCMKGAVTITILLGVFIFCWAPFFLHLVLIITCPTNPYCICYTAHFNTYLVLIMCNSVIDPLIYAFRSLELRNTFREILCGCNGMNLG
Inhibitor
Name:
BDBM50191558
Synonyms:
CHEMBL212976 | N-((R)-1-((2S,4R)-2-(3-guanidinopropyl)-4-(naphthalen-2-yl-methoxy)pyrrolidin-1-yl)-1-oxo-3-phenylpropan-2-yl)-3-phenylpropanamide
Type:
Small organic molecule
Emp. Form.:
C37H43N5O3
Mol. Mass.:
605.769
SMILES:
[#7]\[#6](-[#7])=[#7]\[#6]-[#6]-[#6]-[#6@H]-1-[#6]-[#6@H](-[#6]-[#7]-1-[#6](=O)-[#6@@H](-[#6]-c1ccccc1)-[#7]-[#6](=O)-[#6]-[#6]-c1ccccc1)-[#8]-[#6]-c1ccc2ccccc2c1